Intestinal stents: Structure, functionalization and advanced engineering innovation

Yusheng Feng; Yufeng Chen; Ying Chen; Xiaowen He; Yousef Khan; Hong Hu; Ping Lan; Yi Li; Xiaoqin Wang; Gang Li; David Kaplan

doi:10.1016/j.bioadv.2022.212810

Intestinal stents: Structure, functionalization and advanced engineering innovation

Biomater Adv. 2022 Jun:137:212810. doi: 10.1016/j.bioadv.2022.212810. Epub 2022 Apr 29.

Authors

Yusheng Feng¹, Yufeng Chen², Ying Chen³, Xiaowen He², Yousef Khan³, Hong Hu⁴, Ping Lan², Yi Li⁵, Xiaoqin Wang¹, Gang Li⁶, David Kaplan⁷

Affiliations

¹ National Engineering Laboratory for Modern Silk, College of Textile and Clothing Engineering, Soochow University, Suzhou 215123, Jiangsu, China.
² Department of Colorectal Surgery, Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou 510655, Guangdong, China.
³ Department of Biomedical Engineering, Tufts University, 4 Colby Street, Medford, MA 02155, USA.
⁴ Institute of Textiles and Clothing, The Hong Kong Polytechnic University, Kowloon, Hong Kong, China.
⁵ Department of Materials, University of Manchester, Oxford Road, Manchester M13 9PL, UK.
⁶ National Engineering Laboratory for Modern Silk, College of Textile and Clothing Engineering, Soochow University, Suzhou 215123, Jiangsu, China. Electronic address: tcligang@suda.edu.cn.
⁷ Department of Biomedical Engineering, Tufts University, 4 Colby Street, Medford, MA 02155, USA. Electronic address: david.kaplan@tufts.edu.

PMID: 35929235
DOI: 10.1016/j.bioadv.2022.212810

Abstract

Intestinal stents are a palliative treatment option that solves many shortcomings of traditional surgeries for cancer-induced intestinal obstructions. The present review provides an overview of the incidence, clinical manifestations and limitations in the treatment of intestinal cancers. The paper also discusses material property requirements, indications, complications and the future of stent-assisted therapy. The advantages and disadvantages of different materials and processing techniques for intestinal stents are reviewed along with new stent treatment combinations for colorectal cancer. Challenges that require further cooperative studies are also detailed. The future development of intestinal stents will depend on innovation in material designs as well as the utilization of multi-functional strategies and innovative engineering solutions.

Keywords: Biodegradable; Colorectal cancer; Drug delivery; Functionalization; Intestinal stents.

Publication types

Review

MeSH terms

Colorectal Neoplasms* / surgery
Humans
Intestinal Obstruction* / etiology
Palliative Care / methods
Stents* / adverse effects
Treatment Outcome