Follicular Porokeratoma: Report of a New Variant of Porokeratoma (Porokeratotic Acanthoma) and Literature Review

Am J Dermatopathol. 2022 Oct 1;44(10):748-752. doi: 10.1097/DAD.0000000000002271. Epub 2022 Jul 28.

Abstract

Porokeratoma is a rare type of epidermal acanthoma, of which 22 cases have been published in the literature. It is characterized by the presence of multiple cornoid lamellae embedded within a single verrucous or keratotic nodule. Despite this histologic feature being shared with porokeratosis, the etiopathogenesis of porokeratoma and its relationship with porokeratosis remain unclear. We report a new case of porokeratoma involving hair follicles, a finding that has been reported in only one of the previously published cases. Analogous to follicular porokeratosis, a form of porokeratosis involving hair follicles, we have termed this lesion "follicular porokeratoma." A review of all 23 published cases (including the present case) is also provided.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Acanthoma* / pathology
  • Epidermis / pathology
  • Hair Follicle / pathology
  • Humans
  • Porokeratosis* / pathology
  • Skin Neoplasms* / pathology