Recent advances in macrocyclic arenes-based fluorescent indicator displacement assays

Qunpeng Duan; Fei Wang; Kui Lu

doi:10.3389/fchem.2022.973313

Recent advances in macrocyclic arenes-based fluorescent indicator displacement assays

Front Chem. 2022 Jul 18:10:973313. doi: 10.3389/fchem.2022.973313. eCollection 2022.

Authors

Qunpeng Duan¹, Fei Wang¹, Kui Lu^{1

2}

Affiliations

¹ School of Chemical and Printing-Dyeing Engineering, Henan University of Engineering, Zhengzhou, China.
² School of Chemical Engineering and Food Science, Zhengzhou Institute of Technology, Zhengzhou, China.

Abstract

Macrocyclic arenes-based fluorescent indicator displacement assays (F-IDAs) offer a unique and innovative approach to chemosensing, taking molecular recognition in host-guest chemistry to a higher level. Because of their special architecture and versatile host-guest binding properties, macrocyclic arenes, principally calix[n]arenes and, in recent years, pillar[n]arenes, in combination with various fluorophores, are widely used in F-IDAs for the specific and selective sensing of cationic, anionic, and neutral analytes. In this paper, we review recent progress in the development of F-IDAs based on macrocyclic arenes and outline the prospects and remaining challenges relating to macrocyclic arenes-based F-IDAs.

Keywords: calix[n]arenes; fluorescence; host-guest complex; indicator displacement assay; pillar[n]arenes.

Publication types

Review