Chronotype, chrononutrition and glucose tolerance among prediabetic individuals: research protocol for a prospective longitudinal study Chrono-DM™

Guey Yong Chong; Satvinder Kaur; Ruzita Abd Talib; See Ling Loy; Hui Yin Tan; Sarjit Singh Harjit Singh; Rosmiza Binti Abdullah; Hanisah Binti Mahmud; Woan Yie Siah; Hui Chin Koo

doi:10.1186/s12875-022-01815-7

Chronotype, chrononutrition and glucose tolerance among prediabetic individuals: research protocol for a prospective longitudinal study Chrono-DM™

BMC Prim Care. 2022 Aug 4;23(1):193. doi: 10.1186/s12875-022-01815-7.

Authors

Affiliations

¹ Faculty of Applied Sciences, Tunku Abdul Rahman University College, Kuala Lumpur, Malaysia.
² Faculty of Applied Sciences, UCSI University, Kuala Lumpur, Malaysia.
³ Nutritional Sciences Program, Centre for Community Health Studies (ReaCH), Faculty of Health Sciences, The National University of Malaysia, Kuala Lumpur, Malaysia.
⁴ Department of Reproductive Medicine, KK Women's and Children's Hospital, Singapore, Singapore.
⁵ Duke-NUS Medical School, Singapore, Singapore.
⁶ Hospital Serdang, Sepang, Selangor, Malaysia.
⁷ Klinik Kesihatan Batu Berendam, Pejabat Kesihatan Daerah Melaka Tengah, Melaka, Malaysia.
⁸ Faculty of Applied Sciences, Tunku Abdul Rahman University College, Kuala Lumpur, Malaysia. koohc@tarc.edu.my.

Abstract

Background: Chronotype and chrononutrition, both are emerging research interests in nutritional epidemiology. However, its association with glycemic control in the Asia population is less clear. A better understanding of how activity/eating time can influence glucose levels in Asian prediabetic individuals may improve strategies for blood glucose control in Asian countries. The present paper describes the research protocol which aims to determine the associations of chronotype and chrononutrition with glucose tolerance among Malaysian prediabetic individuals.

Methods: This is a prospective longitudinal study named Chrono-DM™, that targets to recruit 166 newly diagnosed prediabetic individuals from the community clinics in Malacca, Malaysia. Respondents will be followed-up for 6 months: (1) baseline (1^st oral glucose tolerance test (OGTT)); (2) second visit (at 3^rd month); and (3) third visit (2^nd OGTT at 6^th month). Data collection includes sociodemographic and anthropometry measurements (weight, height, body fat, visceral fat, waist and hip circumference). Dietary intake and meal timing are collected using the 3-day dietary record while data on sleep pattern, light exposure, chronotype and chrononutrition will be collected using validated questionnaires. Physical activity will be recorded using a validated IPAQ questionnaire and pedometer during periods of using continuous glucose monitoring (CGM) sensor. CGM, fasting blood sugar (FBS), OGTT and HbA1c are performed to assess glycemic outcomes.

Discussion: The Chrono-DM™ study represents a novel approach to determining the association of chronotype and chrononutrition with glycemic control. We anticipate that this study will not only review the association of chronotype with glycemia measure but also provide greater insight into optimal meal time for glycemic control among prediabetic individuals in the Asian population.

Trial registration: NCT05163964 (Clinicaltrial.gov). Trial registration date: 20 December 2021.

Keywords: Chrononutrition; Chronotype; Glucose tolerance; Glycemic outcomes; Longitudinal study; Meal timing; Prediabetes.

Publication types

Clinical Study
Research Support, Non-U.S. Gov't

MeSH terms

Blood Glucose
Blood Glucose Self-Monitoring
Humans
Longitudinal Studies
Prediabetic State* / epidemiology
Prospective Studies

Substances

Blood Glucose

Associated data

ClinicalTrials.gov/NCT05163964