Seroprevalence of Kaposi's sarcoma-associated herpesvirus and risk factors in Jiuquan area, China

Yuan Fang; Wenli Li; Ying Zhang; Chang Zhou; Huanwu Wu; Yiting Zhang; Tao Dai; Jinzhi Wang; Lei Wang; Tongqing Chen; Yulin Zhu; Linding Wang

doi:10.1002/jmv.28045

Seroprevalence of Kaposi's sarcoma-associated herpesvirus and risk factors in Jiuquan area, China

J Med Virol. 2022 Dec;94(12):6016-6022. doi: 10.1002/jmv.28045. Epub 2022 Aug 17.

Authors

Yuan Fang^{1

2}, Wenli Li², Ying Zhang³, Chang Zhou², Huanwu Wu², Yiting Zhang², Tao Dai⁴, Jinzhi Wang⁵, Lei Wang⁶, Tongqing Chen¹, Yulin Zhu⁷, Linding Wang²

Affiliations

¹ Blood Transfusion Department, Anhui No. 2 Provincial People's Hospital, Hefei, Anhui, China.
² Department of Microbiology and Parasitology, The Key Laboratory of Microbiology and Parasitology of Anhui Province, The Key Laboratory of Zoonoses of High Institutions in Anhui, School of Basic Medical Sciences, Anhui Medical University, Hefei, Anhui, China.
³ Department of Clinical Laboratory, The First Affiliated Hospital of Bengbu Medical College, Bengbu, Anhui, China.
⁴ Second Clinical Medical College, Anhui Medical University, Hefei, Anhui, China.
⁵ School of Basic Medical Sciences, Anhui Medical University, Hefei, Anhui, China.
⁶ Department of Orthopedics, The Third People's Hospital of Hefei, Third Clinical College, Anhui Medical University, Hefei, Anhui, China.
⁷ Department of Pediatrics, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China.

PMID: 35922376
DOI: 10.1002/jmv.28045

Abstract

The seroprevalence of Kaposi's sarcoma-associated herpesvirus (KSHV) is high in Xinjiang, China. But the seroprevalence of KSHV and risk factors are still unknown in Gansu which is adjacent to Xinjiang. Six hundred and seventy-eight serum samples of the general population and 87 serum samples of syphilis patients from Jiuquan, Gansu were tested for antibodies against KSHV, including one latent protein (ORF73) and two lytic proteins (ORF65 and K8.1) using the ELISA. The total KSHV-seropositive rate was 15.9% in 678 serum samples in the Jiuquan area, and the KSHV-seropositive rate of males was higher than females (18.0% vs. 14.6%, p > 0.05). The Uygur, Kazakh, Hui, Manchu, and Mongolian populations had a higher seroprevalence of KSHV than the Han population (43.8%, 40.0%, 34.5%, 30.3%, 35.0% vs. 11.0%, respectively) among the ethnic groups in Jiuquan. Compared to the Han, Uygur, Kazak, Hui, Manchu, and Mongolian people had an increase in the risk of KSHV of 528.9%, 439.1%, 325.6%, 251.6%, and 335.4% (p < 0.001, p < 0.001, p < 0.001, p = 0.002, p = 0.003, respectively). The serum prevalence of KSHV in subjects aged < 20 years, 20-50 years, and >50 years was 13.8%, 14.7%, and 20.1%, respectively. Compared to the subjects aged < 20 years, 20-50 years and >50 years had an increase in the risk of KSHV of 7.4% and 56.9% (p = 0.829 and p = 0.204, respectively). Compared to the positive rate of KSHV in the general population of Anhui, the positive rate of KSHV was significantly higher in the general population of the Jiuquan area (15.9% vs. 9%, p < 0.01). There was no significant difference in the positive rate of KSHV between the Han population of Jiuquan and the Han population of Anhui (p > 0.05). In the population of syphilis patients in the Jiuquan area, the positive rate of KSHV was 30.7%, which was higher than that of the general population in the Gansu area (p < 0.05). This study indicates that Gansu has a high seroprevalence of KSHV. Ethnicity and syphilis are risk factors for KSHV infection.

Keywords: epidemiology; herpesvirus; human herpesvirus 8 (Kaposi sarcoma-associated herpesvirus).

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Antibodies, Viral
China / epidemiology
Female
Herpesvirus 8, Human*
Humans
Male
Risk Factors
Sarcoma, Kaposi*
Seroepidemiologic Studies
Syphilis*

Substances

Antibodies, Viral