Nutrient sensing mechanism of short-chain fatty acids in mastitis control

Ilyas Ali; Ahmad Raza; Muhammad Arslan Ahmad; Lian Li

doi:10.1016/j.micpath.2022.105692

Nutrient sensing mechanism of short-chain fatty acids in mastitis control

Microb Pathog. 2022 Sep:170:105692. doi: 10.1016/j.micpath.2022.105692. Epub 2022 Jul 31.

Authors

Ilyas Ali¹, Ahmad Raza², Muhammad Arslan Ahmad³, Lian Li⁴

Affiliations

¹ Department of Medical Cell Biology and Genetics, Health Sciences Center, Shenzhen University, Shenzhen, 518060, China; College of Animal Science and Technology, Nanjing Agricultural University, Nanjing, 210095, China.
² Faculty of Veterinary Sciences, Bahauddin Zakariya University, Multan, Pakistan.
³ College of Life Sciences and Oceanography, Shenzhen University, Shenzhen, 518060, China.
⁴ College of Animal Science and Technology, Nanjing Agricultural University, Nanjing, 210095, China. Electronic address: lilian@njau.edu.cn.

PMID: 35921952
DOI: 10.1016/j.micpath.2022.105692

Abstract

Bovine mastitis is a disease that is widespread in dairy cows worldwide, and its impact is significant due to economic losses at all levels of the dairy value chain. For a long time, antibiotics have been the main tool for curing mastitis, however the cure rate is not very high, and sometime side effects may occur. Therefore, an in-depth understanding of mastitis and effective solutions are urgently needed to resolve the problem that in what way to prevent and treat mastitis in order to protect the profitability of dairy farms. The importance of diet in the regulation of health are not novel. Dietary control of the intestinal flora provides a promising approach to prevent or treat certain deadly diseases. Ample amount of studies has been conducted on the role of short-chain fatty acids (SCFAs) in the maintenance of health. SCFAs are the type of dietary substance that has the ability to restore blood-milk barrier permeability, inhibit the development of mammary inflammation, and are also effective epigenomic modifiers with histone deacetylases inhibitory activity. To date, the detailed mechanism of action of SCFAs in treating mastitis is unclear, but preliminary evidences are emerging. To assess the effectiveness of this recommendation, we examined the overall mammary gland health knowledge related to SCFAs by scrutinizing their potential role and evaluating its compatibility with the immunobiology of mammary gland inflammation. We then considered preliminary in vivo and in vitro experiments and analyzed the literature on the subject. Here, we outline the production of SCFAs and its protective effect on the mammary gland, with particular emphasis on their relevance to mastitis. In addition, we also discussed the therapeutic potential of SCFAs for mammary gland inflammation. Expectantly, this theory will provide new perception for the treatment of mastitis and other infectious diseases.

Keywords: Antibiotics; Epigenetics; Mammary gland; Mastitis; Short-chain fatty acids.

Publication types

Review

MeSH terms

Animals
Cattle
Fatty Acids, Volatile / therapeutic use
Female
Humans
Inflammation
Mammary Glands, Animal
Mastitis, Bovine* / drug therapy
Mastitis, Bovine* / prevention & control
Milk
Nutrients

Substances

Fatty Acids, Volatile