Abstract
The posterior HOXD enhancer is an EWSR1::FLI1-dependent regulator of HOXD13 expression in Ewing sarcoma. HOXD13 expression promotes a mesenchymal cell state. Through antagonistic transcriptional programs, EWSR1::FLI1 and HOXD13 serve as master regulators of Ewing cell plasticity. Targeting Ewing cells as they exist in/transition between mesenchymal states is a priority. See related article by Apfelbaum et al., p. 4466.
©2022 American Association for Cancer Research.
Publication types
-
Research Support, N.I.H., Extramural
-
Research Support, Non-U.S. Gov't
-
Comment
MeSH terms
-
Cell Line, Tumor
-
Gene Expression Regulation, Neoplastic
-
Humans
-
Oncogene Proteins, Fusion / genetics
-
Oncogene Proteins, Fusion / metabolism
-
Proto-Oncogene Protein c-fli-1 / genetics
-
Proto-Oncogene Protein c-fli-1 / metabolism
-
RNA-Binding Protein EWS / genetics
-
RNA-Binding Protein EWS / metabolism
-
Sarcoma, Ewing* / drug therapy
-
Sarcoma, Ewing* / genetics
-
Sarcoma, Ewing* / metabolism
-
Transcription Factors / genetics
-
Transcription Factors / metabolism
Substances
-
Oncogene Proteins, Fusion
-
Proto-Oncogene Protein c-fli-1
-
RNA-Binding Protein EWS
-
Transcription Factors