1 From the Institute of Clinical Medicine, Aarhus University (STV), Department of Anaesthesiology & Intensive Care, Aarhus University Hospital, Denmark (STV), Laboratory for Computational Physiology, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA (TJP), Department of Critical Care, University College London Hospital and Institute of Health Informatics, University College London, UK (SH) and Enversion A/S, Denmark (SML).