Physical and Chemical Cues at the Nano-Bio Interface for Immunomodulation

Feng-Yuan Wang; Tianze Qiu; Yun Ling; Yannan Yang; Yaming Zhou

doi:10.1002/anie.202209499

Physical and Chemical Cues at the Nano-Bio Interface for Immunomodulation

Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202209499. doi: 10.1002/anie.202209499. Epub 2022 Sep 1.

Authors

Feng-Yuan Wang¹, Tianze Qiu¹, Yun Ling¹, Yannan Yang², Yaming Zhou¹

Affiliations

¹ Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials, Department of Chemistry, Fudan University, Shanghai, 200433, China.
² Australian Institute for Bioengineering and Nanotechnology, The University of Queensland St Lucia, Brisbane, 4072, Australia.

PMID: 35918849
DOI: 10.1002/anie.202209499

Abstract

Immunomodulation has made remarkable progress in fighting infectious disease and cancer. Conventionally, immunomodulation largely relies on chemical/biochemical agents, which, unfortunately, suffer from sever off-target adverse effects. Recent insights into nano-bio interactions suggest that nanomaterials can directly participate in immunomodulation. A range of physical and chemical cues at the nano-bio interface have been harnessed to regulate diverse immuno-signaling for disease control and treatment. In this Minireview, we summarize recent studies on the physical and chemical cues enabled by intrinsic nanomaterials to trigger immunological signaling. First, we discuss physical cues mediated by surface topography, hydrophobicity, charge, and heat at the nano-bio interface for immunomodulation. Then, various nanomaterials enabled chemical cues, such as metal species and oxidative species are outlined. Finally, our perspectives on challenges and possible future directions are provided.

Keywords: Antitumor Agents; Immunomodulation; Inflammatory Response; Interfaces; Nano-Bio Interfaces.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Cues*
Immunomodulation
Metals
Nanostructures*
Oxidation-Reduction

Substances

Metals