Solid state of inhalable high dose powders

Bishal Raj Adhikari; Keith C Gordon; Shyamal C Das

doi:10.1016/j.addr.2022.114468

Solid state of inhalable high dose powders

Adv Drug Deliv Rev. 2022 Oct:189:114468. doi: 10.1016/j.addr.2022.114468. Epub 2022 Jul 30.

Authors

Bishal Raj Adhikari¹, Keith C Gordon², Shyamal C Das³

Affiliations

¹ School of Pharmacy, University of Otago, Dunedin 9054, New Zealand.
² The Dodd-Walls Centre for Photonic and Quantum Technologies, Department of Chemistry, University of Otago, Dunedin 9016, New Zealand.
³ School of Pharmacy, University of Otago, Dunedin 9054, New Zealand. Electronic address: shyamal.das@otago.ac.nz.

PMID: 35917868
DOI: 10.1016/j.addr.2022.114468

Abstract

High dose inhaled powders have received increased attention for treating lung infections. These powders can be prepared using techniques such as spray drying, spray-freeze drying, crystallization, and milling. The selected preparation technique is known to influence the solid state of the powders, which in turn can potentially modulate aerosolization and aerosolization stability. This review focuses on how and to what extent the change in solid state of high dose powders can influence aerosolization. It also discusses the commonly used solid state characterization techniques and the application of potential strategies to improve the physical and chemical stability of the amorphous powders for high dose delivery.

Keywords: Aerosolization; Amorphous; Antibiotic; Chemical stability; Co-amorphous; Crystalline; Dry powder inhaler; Lung infection; Pulmonary drug delivery.

Publication types

Review

MeSH terms

Administration, Inhalation
Aerosols
Dry Powder Inhalers*
Humans
Particle Size
Powders

Substances

Aerosols
Powders