Microdystrophin Therapy Rescues Impaired Na Currents in Cardiac Purkinje Fibers From Dystrophin-Deficient Mdx Mice

Circ Arrhythm Electrophysiol. 2022 Aug;15(8):e011161. doi: 10.1161/CIRCEP.122.011161. Epub 2022 Aug 2.

Authors

Janine Ebner^#¹, Xiufang Pan^#², Yongping Yue², Spyridon Sideromenos¹, Jessica Marksteiner¹, Xaver Koenig¹, Karlheinz Hilber¹, Dongsheng Duan^{2

3}

Affiliations

¹ Department of Neurophysiology & Neuropharmacology, Center for Physiology & Pharmacology, Medical University of Vienna, Vienna, Austria (J.E., S.S., J.M., X.K., K.H.).
² Department of Molecular Microbiology & Immunology (X.P., Y.Y., D.D.).
³ Department of Neurology, Department of Biomedical Sciences, and Department of Biological & Chemical Engineering, The University of Missouri, Columbia, MO (D.D.).

^# Contributed equally.

No abstract available

Keywords: arrhythmia, cardiac; dystrophin; mice; muscular dystrophy, Duchenne; myocytes, cardiac.

Publication types

Letter
Research Support, Non-U.S. Gov't
Research Support, N.I.H., Extramural

MeSH terms

Animals
Dystrophin* / genetics
Mice
Mice, Inbred C57BL
Mice, Inbred mdx
Muscular Dystrophy, Duchenne* / genetics
Muscular Dystrophy, Duchenne* / therapy
Purkinje Fibers
Sodium

Substances

Dystrophin
Sodium

Grants and funding