Drug-associated bone resorption with potential dental and implant implications

Periodontol 2000. 2022 Oct;90(1):236-246. doi: 10.1111/prd.12461. Epub 2022 Aug 2.

Abstract

Every year more and more innovative pharmacological agents are introduced medicine, to treat systemic diseases. Due to these rapid and recent advancements, many patients are receiving treatment with a high variety of drugs, such as selective serotonin reuptake inhibitors, bisphosphonates, tumor necrosis factor (TNF)-α inhibitors, cyclosporine, and steroids. Since implant and osseous surgery are common treatment modalities used, within dentistry, it is of critical important to acknowledge and discuss the potential effects of selective serotonin reuptake inhibitors, bisphosphonates, TNF-α inhibitors, cyclosporine, and steroids, on bone healing. The present paper discusses the possible detrimental ramifications and risks these drug classes may have on bone healing.

Keywords: bone resorption; drugs; implant complications.

Publication types

  • Review

MeSH terms

  • Bone Resorption* / chemically induced
  • Cyclosporins*
  • Dental Implants* / adverse effects
  • Diphosphonates / adverse effects
  • Humans
  • Selective Serotonin Reuptake Inhibitors / adverse effects
  • Tumor Necrosis Factor-alpha

Substances

  • Cyclosporins
  • Dental Implants
  • Diphosphonates
  • Serotonin Uptake Inhibitors
  • Tumor Necrosis Factor-alpha