Portal vein thrombosis as a thrombotic complication of COVID-19 mRNA vaccine: A case report and literature review

Prakriti Singh Shrestha; Angela Ishak; Arun R Napit; Sarosh Sarwar; Niraj Rai; Zoha Nizami; Niharika Bheemisetty; Prashanth Jayaraj; Amardeep Shrestha; Ivan D Rodriguez

doi:10.1016/j.idcr.2022.e01582

Portal vein thrombosis as a thrombotic complication of COVID-19 mRNA vaccine: A case report and literature review

IDCases. 2022:29:e01582. doi: 10.1016/j.idcr.2022.e01582. Epub 2022 Jul 26.

Authors

Affiliations

¹ Department of Research and Academic Affairs, Larkin Community Hospital, South Miami, FL, USA.
² Family Medical Clinic, O'Fallon, IL, USA.
³ Valley Health and Research Center, Srijananagar, Bhaktapur, Nepal.
⁴ Fazaia Medical College, Islamabad, Pakistan.
⁵ University of Health Sciences, Lahore, Pakistan.
⁶ Department of Family Medicine, Larkin Community Hospital, South Miami, FL, USA.

Abstract

Thrombosis following COVID-19 vaccination commonly occurs with vector-based vaccines. The proposed mechanism is vaccine-induced thrombotic thrombocytopenia (VITT), with thrombocytopenia as principal manifestation. We present a 51-year-old male who came with isolated portal vein thrombosis (PVT) one day after Moderna vaccination, without associated thrombocytopenia, challenging VITT as being the only patho-mechanism. Further exploration of these possible alternative mechanisms is needed for COVID-19 vaccine-related thrombotic complications.

Keywords: COVID-19 vaccine; Portal vein thrombosis; VITT.

Publication types

Case Reports