Pcv-aCO2 and procalcitonin levels for the early diagnosis of bloodstream infections caused by gram-negative bacteria

Abstract

Background: The central venous-to-arterial carbon dioxide difference (Pcv-aCO₂) is a biomarker for tissue perfusion, but the diagnostic value of Pcv-aCO₂ in bacteria bloodstream infections (BSI) caused by gram-negative (GN) bacteria remains unclear. This study evaluated the expression levels and diagnostic value of Pcv-aCO₂ and procalcitonin (PCT) in the early stages of GN bacteria BSI.

Methods: Patients with BSI admitted to the intensive care unit at Guangdong Provincial People's Hospital between August 2014 and August 2017 were enrolled. Pcv-aCO₂ and PCT levels were evaluated in GN and gram-positive (GP) bacteria BSI patients.

Results: A total of 132 patients with BSI were enrolled. The Pcv-aCO₂ (8.32 ± 3.59 vs 4.35 ± 2.24 mmHg p = 0.001) and PCT (30.62 ± 34.51 vs 4.92 ± 6.13 ng/ml p = 0.001) levels were significantly higher in the GN group than in the GP group. In the diagnosis of GN bacteria BSI, the area under the receiver operating characteristic curve (AUROC) for Pcv-aCO₂ was 0.823 (95% confidence interval (CI): 0.746-0.900). The sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV) were 71.90%, 88.00%, 74.07% and 78.21%, respectively. The AUROC for PCT was 0.818 (95% CI: 0.745-0.890). The sensitivity, specificity, PPV and NPV were 57.90%, 94.67%, 71.93% and 74.67%, respectively.

Conclusions: Pcv-aCO₂ and PCT have similar and high diagnostic value for the early diagnosis of BSI caused by GN bacteria.

Keywords: Bloodstream infection; Central venous-to-arterial carbon dioxide difference; Diagnosis; Gram-negative bacteria; Procalcitonin.