We propose and demonstrate a passively biased 2 × 2 thermo-optic switch with high power efficiency and fast response time. The device benefits from the highly concentrated optical field of a slot waveguide mode and the strong thermo-optic effect of a nematic liquid crystal (NLC) cladding. The NLC fills the nano-slot region and is aligned by the subwavelength grating inside. The measured power consumption and thermal time constant are 0.58 mW and 11.8 µs, respectively, corresponding to a figure-of-merit of 6.8 mW µs. The proposed silicon-organic hybrid device provides a new solution to design thermo-optic actuators having low power consumption and fast operation speed.