Case Report: Next-Generation Sequencing-Based Detection in A Patient with Three Synchronous Primary Tumors

Tianqi Wu; Jian Wan; Kai Xia; Muqing Yang; Lijin Feng; Lu Yin; Chunqiu Chen

doi:10.3389/fonc.2022.910264

Case Report: Next-Generation Sequencing-Based Detection in A Patient with Three Synchronous Primary Tumors

Front Oncol. 2022 Jul 15:12:910264. doi: 10.3389/fonc.2022.910264. eCollection 2022.

Authors

Tianqi Wu¹, Jian Wan¹, Kai Xia¹, Muqing Yang¹, Lijin Feng², Lu Yin¹, Chunqiu Chen¹

Affiliations

¹ Center for Difficult and Complicated Abdominal Surgery, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, China.
² Department of Pathology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, China.

Abstract

Clinically rare, multiple primary tumors are a growth or development of two or more neoplasms in the same individual. A 57-year-old woman with two primary cancers, namely, breast and gastric cancers, and a gastrointestinal stromal tumor was admitted. Next-generation sequencing (NGS) of the three tumors and blood was performed to determine their clonal origin and identify genetic cancer susceptibility. NGS identified that germline genetic variants potentially correlated with an individual risk of developing multiple cancers and that additional mutations are required to drive the formation of different tumors.

Keywords: BC; BRCA2; GIST; MPT; NGS.

Publication types

Case Reports