Jaw bone metastasis from Lung cancer as sole primary source: A systematic review

Sonia Gupta; Manveen-Kaur Jawanda; Aruna Ganganna; Suman Basavaraju; Neha Kashav; Jayata Dhawan; Sumit-Kumar Yadav; Achla-Bharti Yadav

doi:10.4317/jced.59554

Jaw bone metastasis from Lung cancer as sole primary source: A systematic review

J Clin Exp Dent. 2022 Jul 1;14(7):e573-e593. doi: 10.4317/jced.59554. eCollection 2022 Jul.

Authors

Sonia Gupta¹, Manveen-Kaur Jawanda², Aruna Ganganna³, Suman Basavaraju⁴, Neha Kashav⁵, Jayata Dhawan⁶, Sumit-Kumar Yadav⁷, Achla-Bharti Yadav⁸

Affiliations

¹ MDS, Reader, Department of Oral Pathology and Microbiology & Forensic odontology, Rayat and Bahra Dental college and hospital, Mohali, Punjab, India.
² MDS, Professor & Head, Department of Oral Pathology and Microbiology & Forensic odontology. Laxmi bai institute of dental sciences and hospital, Patiala, Punjab, India.
³ MDS, Assistant Professor, Department of Periodontology, JSS Dental College and Hospital, Mysore, Karnataka, India.
⁴ MDS, Reader, Department of Periodontology, JSS Dental College and Hospital, Mysore, Karnataka, India.
⁵ MDS, Senior Lecturer, Department of Pediatric and Preventive Dentistry, Bhojia Dental College and Hospital, Baddi, HP, India.
⁶ MDS, Senior Lecturer, Department of Pediatric and Preventive Dentistry, MM College of Dental Sciences and Research, Mullana, Haryana, India.
⁷ MDS, Professor, Department of Orthodontics & Dentofacial Orthopedics, D J College of Dental Sciences & Research, Modinagar, UP, India.
⁸ MDS, Professor, Department of Oral Pathology & Microbiology, D J College of Dental Sciences and Research, Modinagar, UP, India.

Abstract

Background: Lung cancer is one of the leading causes of death worldwide. Lung cancer metastasis to oral region is very rare. Very few research work has been conducted till date to analyse the jaw bone metastasis from Lung cancer as the primary source. The goal of this research was to examine published cases of jaw bone metastasis from lung cancer as the sole primary source from 1st December 1961 to 31st December 2021 and to learn about their characteristics.

Material and methods: An electronic search of the published English literature was performed in PubMed/ Medline, Scopus, Google Scholar, and Research gate databases, using keywords like 'Lung cancer', OR/AND 'Lung carcinoma', OR/AND 'Metastasis', OR/AND 'Primary', OR/AND 'Source', OR/AND 'Oral cavity' OR/AND 'Jaw', OR/ AND 'Mandible', OR/AND 'Maxilla', OR/ AND 'Temporomandibular joint', OR/ AND 'Condyle', OR/ AND 'Ramus', OR/ AND 'Maxillary sinus', AND Initial', OR/ AND 'Treatment', OR/AND 'Prognosis', OR/ AND 'Follow-up', OR/AND 'Recurrence', OR/ AND 'Survival rate'. We also searched all related journals manually. Reference list of all articles was also checked. Data extracted were tabulated and summarized.

Results: In total, we found 60 relevant publications with 66 patients in our research. The prognosis was poor, with a survival time of 1 week to 1.5 years. The most prevalent diagnosed metastatic lung cancer to jaw bones was adenocarcinoma and mandible was the predominant site.

Conclusions: Jaw bone metastasis from lung cancer is rare and has a bad prognosis. Because of their resemblance to other jaw problems and late clinical signs, these lesions go unnoticed the majority of the time, making detection difficult. More cases need to be published in order to raise awareness of these lesions and gain a better understanding of their characteristics. Key words:Jaw bone, lung cancer, metastasis, primary, prognosis.

Publication types

Review