Role and mechanism of miR-211 in human cancer

Lingling Ye; Fen Wang; Jinyan Wang; Hao Wu; Hui Yang; Zhaohui Yang; Haiwei Huang

doi:10.7150/jca.71401

Role and mechanism of miR-211 in human cancer

J Cancer. 2022 Jul 18;13(9):2933-2944. doi: 10.7150/jca.71401. eCollection 2022.

Authors

Lingling Ye¹, Fen Wang², Jinyan Wang², Hao Wu², Hui Yang², Zhaohui Yang², Haiwei Huang¹

Affiliations

¹ Department of Gynecology, Zhangjiagang First People's Hospital, Zhangjiagang Affiliated Hospital of Soochow University, Zhangjiagang, Jiangsu, China; Department of Oncology, The Affiliated Jiangning Hospital with Nanjing Medical University, Nanjing, Jiangsu, China.
² Department of Oncology, The Affiliated Jiangning Hospital with Nanjing Medical University, Nanjing, Jiangsu, China.

Abstract

MircoRNA (miRNA), which are a group of small, and highly conserved non-coding RNA consisting of 18-25 nucleotides, can modulate gene expression at post-transcriptional level, through complementary binding to the 3'-untranslated region (3'-UTR) of numerous target genes. Emerging evidence indicates that miRNAs play critical roles in tumorigenesis and progression of cancer. Among them, miR-211 has been extensively studied in multiple cancers. The expression of miR-211 significantly varies with cancer types and may be used as a potential prognostic marker for cancer. MiR-211 can regulate multiple biological processes in cancer, including proliferation, apoptosis, metastasis and drug resistance. Additionally, several factors may contribute to the dysregulation of miR-211 in cancer. Consequently, this review aims to discuss the novel findings that highlight latent value of miR-211 in the prognosis assessment and treatment of cancer.

Publication types

Review