Effects of Metabolism on Macrophage Polarization Under Different Disease Backgrounds

Jia-Xue Sun; Xiang-Hong Xu; Liping Jin

doi:10.3389/fimmu.2022.880286

Effects of Metabolism on Macrophage Polarization Under Different Disease Backgrounds

Front Immunol. 2022 Jul 14:13:880286. doi: 10.3389/fimmu.2022.880286. eCollection 2022.

Authors

Jia-Xue Sun¹, Xiang-Hong Xu¹, Liping Jin¹

Affiliation

¹ Shanghai Key Laboratory of Maternal-Fetal Medicine, Department of Biobank, Clinical and Translational Research Center, Shanghai First Maternity and Infant Hospital, School of Medicine, Tongji University, Shanghai, China.

Abstract

Macrophages are versatile immune cells associated with various diseases, and their phenotypes and functions change on the basis of the surrounding environments. Reprogramming of metabolism is required for the proper polarization of macrophages. This review will focus on basic metabolic pathways, the effects of key enzymes and specific products, relationships between cellular metabolism and macrophage polarization in different diseases and the potential prospect of therapy targeted key metabolic enzymes. In particular, the types and characteristics of macrophages at the maternal-fetal interface and their effects on a successful conception will be discussed.

Keywords: macrophage; maternal-fetal interface; metabolism; polarization; pregnancy.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Macrophage Activation*
Macrophages*
Phenotype