Bacterial-Type Long-Chain Polyphosphates Bind Human Proteins in the Phosphatidylinositol Signaling Pathway

Viola Krenzlin; Julian Roewe; Marcel Strueve; María Martínez-Negro; Arjun Sharma; Christoph Reinhardt; Svenja Morsbach; Markus Bosmann

doi:10.1055/s-0042-1751280

Bacterial-Type Long-Chain Polyphosphates Bind Human Proteins in the Phosphatidylinositol Signaling Pathway

Thromb Haemost. 2022 Nov;122(11):1943-1947. doi: 10.1055/s-0042-1751280. Epub 2022 Jul 30.

Authors

Viola Krenzlin¹, Julian Roewe¹, Marcel Strueve¹, María Martínez-Negro², Arjun Sharma^{1

3}, Christoph Reinhardt¹, Svenja Morsbach², Markus Bosmann^{1

3}

Affiliations

¹ Center for Thrombosis and Hemostasis, University Medical Center Mainz, Mainz, Germany.
² Department of Physical Chemistry of Polymers, Max Planck Institute for Polymer Research, Mainz, Germany.
³ Department of Medicine, Pulmonary Center, Boston University School of Medicine, Boston, Massachusetts, United States.

Abstract

A human proteome microarray was probed with long-chain polyphosphates. Several of the identified proteins (DAB1, PIP4K2B) were further validated using small-scale assays. The depicted proteins shared the common feature of a functional relationship to the PI3K/Akt signaling pathway.

Publication types

Letter

MeSH terms

Bacteria
Humans
Phosphatidylinositols
Polyphosphates* / metabolism
Signal Transduction*

Substances

Polyphosphates
Phosphatidylinositols

Grants and funding

R01 AI153613/AI/NIAID NIH HHS/United States