Time spent within vehicles' cabin has been largely increased during the last years. As a result, the assessment of indoor dust quality is meaningful since dust can be a source of numerous emerging contaminants associated with adverse effects in human health. To this end, fourteen cars and ten trucks from the city of Thessaloniki, Northern Greece were selected to assess the quality of vehicles' microenvironments. An HRMS-based strategy was deployed for the target and non-target analysis of the collected samples. The target approach aimed at the accurate mass screening of nine organophosphate flame retardants (OPFRs) and nine per-/polyfluorinated compounds (PFAS), revealing mean concentrations for the OPFRs varied from <MQL-3409 ng/g for tris(1,3-dichloro-2-propyl) phosphate (TDCP), while the PFASs were either not detected (<MDL) or detected below the quantification limit (<MQL). To exploit the advanced technology of HRMS, a non-target analysis (NTA) workflow was also designed and employed, allowing the identification of 17 non-targets (plasticizers, PPCPs, pesticides and industrial chemicals) at identification confidence levels from 3 to 1. The statistical analysis between the positive findings and vehicles' conditions evidenced a possible of association just for individual cases. Lastly, a preliminary evaluation of human exposure to the target analytes was applied with the view to assess the potential harmful effects. All values were < 1 indicating no special effects because of exposure to this concentration level.
Keywords: HRMS; In-vehicle air quality; Micro-environments; OPFR; PFAS; Validation.
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