Bioprinting-assisted tissue assembly to generate organ substitutes at scale

Yeonggwon Jo; Dong Gyu Hwang; Myungji Kim; Uijung Yong; Jinah Jang

doi:10.1016/j.tibtech.2022.07.001

Bioprinting-assisted tissue assembly to generate organ substitutes at scale

Trends Biotechnol. 2023 Jan;41(1):93-105. doi: 10.1016/j.tibtech.2022.07.001. Epub 2022 Jul 28.

Authors

Yeonggwon Jo¹, Dong Gyu Hwang¹, Myungji Kim¹, Uijung Yong², Jinah Jang³

Affiliations

¹ School of Interdisciplinary Bioscience and Bioengineering, Pohang University of Science and Technology (POSTECH), Pohang, Republic of Korea.
² Department of Convergence IT Engineering, Pohang University of Science and Technology (POSTECH), Pohang, Republic of Korea.
³ School of Interdisciplinary Bioscience and Bioengineering, Pohang University of Science and Technology (POSTECH), Pohang, Republic of Korea; Department of Convergence IT Engineering, Pohang University of Science and Technology (POSTECH), Pohang, Republic of Korea; Department of Mechanical Engineering, Pohang University of Science and Technology (POSTECH), Pohang, Republic of Korea; Institute for Convergence Research and Education in Advanced Technology, Yonsei University, Seoul, Republic of Korea. Electronic address: jinahjang@postech.ac.kr.

PMID: 35907704
DOI: 10.1016/j.tibtech.2022.07.001

Abstract

Various external cues can guide cellular behavior and maturation during developmental processes. Recent studies on bioprinting-assisted tissue engineering have considered this a practical, versatile, and flexible way to provide external cues to developing engineered tissues. An ensemble of multiple external cues can improve the speed and capability of morphogenesis. In this review, we discuss how bioprinting and biomaterials provide multiple guidance to generate micro-sized building blocks with specific shapes and also highlight their applications in tissue assembly toward volumetric tissue and organ generation. Furthermore, we discuss our perspectives on the future translation of bioprinting technologies integrated with artificial intelligence (AI) and robot-assisted apparatus to promote automation, standardization, and clinical translation of bioprinted tissues.

Keywords: 3D bioprinting; biomaterial; tissue assembly; tissue engineering; vascularization.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Artificial Intelligence
Biocompatible Materials
Bioprinting*
Printing, Three-Dimensional
Tissue Engineering
Tissue Scaffolds

Substances

Biocompatible Materials