Aquaporins: Important players in the cardiovascular pathophysiology

Abstract

Aquaporin is a membrane channel protein widely expressed in body tissues, which can control the input and output of water in cells. AQPs are differentially expressed in different cardiovascular tissues and participate in water transmembrane transport, cell migration, metabolism, inflammatory response, etc. The aberrant expression of AQPs highly correlates with the onset of ischemic heart disease, myocardial ischemia-reperfusion injury, heart failure, etc. Despite much attention to the regulatory role of AQPs in the cardiovascular system, the translation of AQPs into clinical application still faces many challenges, including clarification of the localization of AQPs in the cardiovascular system and mechanisms mediating cardiovascular pathophysiology, as well as the development of cardiovascular-specific AQPs modulators.Therefore, in this study, we comprehensively reviewed the critical roles of AQP family proteins in maintaining cardiovascular homeostasis and described the underlying mechanisms by which AQPs mediated the outcomes of cardiovascular diseases. Meanwhile, AQPs serve as important therapeutic targets, which provide a wide range of opportunities to investigate the mechanisms of cardiovascular diseases and the treatment of those diseases.

Keywords: AER-271 (PubChem CID:10412080); Aquaporin; Bacopaside(PubChem CID:21599442); Bumetanide (PubChem CID:2471); Cardiovascular system; Chemical compounds studied in this article Acetazolamide (PubChem CID:1986); HAuCl4 (PubChem CID:10925836); LiCl (PubChem CID: 433294); Localization; Methylene blue (PubChem CID:6099); Modulators; Pathophysiology; Phloretin (PubChem CID:4788); Quercetin (PubChem CID:5280459); TGN-020 (PubChem CID:4173511).