EAAT1-dependent slc1a3 Transcriptional Control depends on the Substrate Translocation Process

ASN Neuro. 2022 Jan-Dec:14:17590914221116574. doi: 10.1177/17590914221116574.

Abstract

EAAT1/GLAST down-regulates its expression and function at the transcriptional level by activating a signaling pathway that includes PI3K, PKC and NF-κB, favoring the notion of an activity-dependent fine-tuning of glutamate recycling and its synaptic transactions through glial cells.

Keywords: Bergmann glia; glutamate transporters; transcriptional control.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Cells, Cultured
  • Excitatory Amino Acid Transporter 1* / genetics
  • Excitatory Amino Acid Transporter 1* / metabolism
  • Gene Expression Regulation* / genetics
  • Glutamic Acid / metabolism
  • Neuroglia / metabolism

Substances

  • Excitatory Amino Acid Transporter 1
  • SLC1A3 protein, human
  • Glutamic Acid