Serum autoantibody markers have the advantages of easy specimen acquisition, simple detection technology and dynamic real-time monitoring. With the wide application of immune checkpoint inhibitors in the treatment of malignant tumors, autoantibody markers in predicting tumor immune checkpoint inhibitors efficacy and forecasting irAEs (immune related adverse events) show good prediction of potential. This review mainly focused on the progress of autoantibody markers in the prediction of therapeutic effect and the monitoring of irAE in tumor immunotherapy. .
【中文题目：自身抗体预后标志物在肿瘤免疫检查点 抑制剂治疗中的临床价值】 【中文摘要：血清自身抗体标志物具有标本易获取、检测技术简便、可实现实时动态监测等优势。随着免疫检查点抑制剂在肿瘤治疗中的广泛应用，自身抗体标志物在肿瘤免疫检查点抑制剂治疗疗效、预后及免疫相关不良事件（immune related adverse events, irAEs）发生预测方面的报道逐渐增多，显示出了良好的预测潜力。本文主要探讨自身抗体标志物在肿瘤免疫治疗疗效、预后及irAE预测方面的研究进展，并对未来前景做出展望。 】 【中文关键词：免疫检查点抑制剂治疗；irAE；自身抗体；预后标志物】.
Keywords: Autoantibody; Immune checkpoint therapy; IrAE; Prognostic marker.