Publication Trends of Research on Gallbladder Cancer During 2001-2021: A 20-Year Bibliometric Analysis

Wentao Sun; Wenze Wan; Zhihui Gao; Tao Suo; Sheng Shen; Houbao Liu

doi:10.3389/fonc.2022.932797

Publication Trends of Research on Gallbladder Cancer During 2001-2021: A 20-Year Bibliometric Analysis

Front Oncol. 2022 Jul 11:12:932797. doi: 10.3389/fonc.2022.932797. eCollection 2022.

Authors

Wentao Sun^{1

2

3}, Wenze Wan^{1

2

3}, Zhihui Gao^{2

3

4}, Tao Suo^{1

2

3}, Sheng Shen^{1

2

3}, Houbao Liu^{1

2

3}

Affiliations

¹ Department of General Surgery, Zhongshan Hospital, Fudan University, Shanghai, China.
² Biliary Tract Disease Institute, Fudan University, Shanghai, China.
³ Shanghai Engineering Research Center of Biliary Tract Minimal Invasive Surgery and Materials, Shanghai, China.
⁴ Department of Nuclear Medicine, Zhongshan Hospital, Fudan University, Shanghai, China.

Abstract

Gallbladder cancer (GBC) is one of the lethal cancers with an extremely poor prognosis. In the recent 20 years, research on GBC has developed rapidly. Here we aim to perform a systematical bibliometric analysis on the current foci and status of GBC research. This study analyzes trends in GBC research and compares contributions from different countries and regions, institutions, and authors. All publications in GBC research from 2001 to 2021 in the Web of Science Core Collection (WoSCC) database were collected. Microsoft Excel 2010 and GraphPad Prism 9 were used to analyze publication data and publication trends. VOSviewer 1.6.17 was adapted to generate a visual network of keywords in surgical training research. A total of 3,323 publications were included. China was the most productive country, with the highest number of publications (n = 900, 27.08%). Shanghai Jiaotong University and Roa JC were the most productive institution and authors, contributing 215 and 89 publications, respectively. Keywords were classified into five clusters, each representing a key topic. The main clusters of GBC are related to surgery therapy, mechanism research-related study, and non-surgery therapy, while migration is the current hotspot of GBC research. The scientific progression of GBC research over the past two decades was comprehensively analyzed by this bibliometric study. Finding deeper mechanisms in the migration of GBC cells, new biomarkers, and highly effective nomograms will be the major problems and directions in the future.

Keywords: Gallbladder cancer (GBC); bibliometric analysis; citation; publication; research.