Hematological Abnormalities and Comorbidities Are Associated With the Severity of Kidney Disease: A Hospital-Based Cross-Sectional Study in Bangladesh

Md Ashrafur Rahman; Yeasna Shanjana; Md Shakil Ahmed; Kuldeep Dhama; Mahadi Hasan Fahim; Tarif Mahmud; Arif Anzum Shuvo; Zahid Hossain Milan; Mohammad Saydur Rahman; Arpita Roy; Mohiuddin Ahmed Bhuiyan; Md Rabiul Islam

doi:10.1177/2632010X221114807

Hematological Abnormalities and Comorbidities Are Associated With the Severity of Kidney Disease: A Hospital-Based Cross-Sectional Study in Bangladesh

Clin Pathol. 2022 Jul 23:15:2632010X221114807. doi: 10.1177/2632010X221114807. eCollection 2022 Jan-Dec.

Affiliations

¹ Department of Pharmaceutical Sciences, North South University, Bashundhara, Dhaka, Bangladesh.
² Department of Environmental Sciences, North South University, Bashundhara, Dhaka, Bangladesh.
³ Division of Pathology, ICAR-Indian Veterinary Research Institute, Izatnagar, Bareilly, Uttar Pradesh, India.
⁴ Critical Care Department, Evercare Hospital, Bashundhara, Dhaka, Bangladesh.
⁵ Department of Pharmacy, Jagannath University, Dhaka, Bangladesh.
⁶ Department of Biotechnology, Sharda University, Greater Noida, Uttar Pradesh, India.
⁷ Department of Pharmacy, University of Asia Pacific, Farmgate, Dhaka, Bangladesh.

Abstract

Background: Abnormalities in hematology and comorbidities might have a role in chronic kidney disease (CKD) patients. However, the exact relationships between hematological parameters and the severity of CKD are not well understood. Also, the underlying mechanisms remain under investigation. The present study aimed to evaluate the association of different blood parameters and comorbidities among hospitalized CKD patients in Bangladesh.

Methods: The present study enrolled admitted CKD patients at Evercare Hospital Ltd, Dhaka, Bangladesh, from January 1, 2021, to August 1, 2021. For this study, the demographic and clinical information of the patients were collected. Then some routine blood tests for the hematological profile of CKD patients were performed. Finally, several statistical methods were performed and data interpretations were done to evaluate the role of hematological changes on CKD patients.

Results: Among 300 patients, early-stage CKD patients (ESCKDP) and advanced-stage CKD patients (ASCKDP) were 153 and 147, respectively. The decreased levels of hemoglobin (Hb) and red blood cell (RBC) in ASCKDP were observed. However, the present study found increased levels of corpuscular Hb in ASCKDP than ESCKDP. Also, the present study noticed correlations between these changes and the severity of CKD. Also, we observed a significant difference in age and body mass index between ESCKDP and ASCKDP.

Conclusions: Based on our results, lower Hb and RBC levels may use in assessing the severity and the treatment decisions of CKD patients in the hospital setting. Therefore, our findings may assist with developing a treatment protocol for hospitalized CKD patients.

Keywords: Kidney disease; hematology; hemoglobin; kidney failure; red blood cell; renal failure; renal insufficiency.