Synthesis and Antiviral Properties of Camphor-Derived Iminothiazolidine-4-Ones and 2,3-Dihydrothiazoles

Molecules. 2022 Jul 25;27(15):4761. doi: 10.3390/molecules27154761.

Abstract

A set of heterocyclic products was synthesized from natural (+)-camphor and semi-synthetic (-)-camphor. Then, 2-Imino-4-thiazolidinones and 2,3-dihydrothiazoles were obtained using a three-step procedure. For the synthesized compounds, their antiviral activity against the vaccinia virus and Marburg virus was studied. New promising agents active against both viruses were found among the tested compounds.

Keywords: Marburg virus; heterocyclic compounds; monoterpenes; monoterpenoids; vaccinia virus.

MeSH terms

  • Antiviral Agents* / pharmacology
  • Camphor* / pharmacology
  • Structure-Activity Relationship
  • Thiazoles / pharmacology

Substances

  • Antiviral Agents
  • Thiazoles
  • 2,3-dihydrothiazole
  • Camphor