Preventive chemotherapy is one of the pivotal interventions for the control and elimination of schistosomiasis, which is effective to reduce the morbidity and prevalence of schistosomiasis. In order to promote the United Nations' sustainable development goals and the targets set for schistosomiasis control in the Ending the neglect to attain the Sustainable Development Goals: a road map for neglected tropical diseases 2021-2030, WHO released the guideline on control and elimination of human schistosomiasis in 2022, with major evidence-based updates of the current preventive chemotherapy strategy for schistosomiasis. In China where great success has been achieved in schistosomiasis control, the preventive chemotherapy strategy for schistosomiasis has been updated several times during the past seven decades. This article reviews the evolution of the WHO guidelines on preventive chemotherapy and Chinese national preventive chemotherapy schemes, compares the current Chinese national preventive chemotherapy scheme and the recommendations for preventive chemotherapy proposed in the 2022 WHO guideline on control and elimination of human schistosomiasis, and proposes recommendations for preventive chemotherapy during the future implementation of the 2022 WHO guideline, so as to provide insights into schistosomiasis control among public health professionals engaging in healthcare foreign aid.
［摘要］ 预防性化疗是控制和消除血吸虫病的重要干预措施之一, 可显著降低发病率和感染率。为推进联合国可持续 发展目标和 WHO《结束忽视, 实现可持续发展目标：2021—2030 年被忽视热带病路线图》中设定的血吸虫病防控目标, 2022 年 WHO 发布了《WHO 控制和消除人体血吸虫病指南》, 基于循证医学证据对血吸虫病化疗策略进行了较大调整。作为血吸虫病防控进程较快的流行国家, 中国在 70 余年的血吸虫病防治历程中对化疗方案也进行了多次调整和修订。本文在回顾 WHO 和中国血吸虫病化疗策略演变过程的基础上, 对中国现行化疗方案和《WHO 控制和消除人体血吸虫病 指南》中的化疗建议进行了比较分析, 并对今后贯彻实施 WHO 指南的化疗策略提出相应建议, 为从事血吸虫病公共卫生 援外工作者和相关人员提供参考。.
Keywords: Elimination; Guideline; Praziquantel; Preventive chemotherapy; Schistosomiasis.