Polymer-Based Hybrid Nanoarchitectures for Cancer Therapy Applications

Arun Kumar; Mirkomil Sharipov; Abbaskhan Turaev; Shavkatjon Azizov; Ismatdjan Azizov; Edwin Makhado; Abbas Rahdar; Deepak Kumar; Sadanand Pandey

doi:10.3390/polym14153027

Polymer-Based Hybrid Nanoarchitectures for Cancer Therapy Applications

Polymers (Basel). 2022 Jul 26;14(15):3027. doi: 10.3390/polym14153027.

Authors

Arun Kumar¹, Mirkomil Sharipov², Abbaskhan Turaev³, Shavkatjon Azizov^{3

4}, Ismatdjan Azizov⁵, Edwin Makhado⁶, Abbas Rahdar⁷, Deepak Kumar¹, Sadanand Pandey⁸

Affiliations

¹ Department of Pharmaceutical Chemistry, School of Pharmaceutical Sciences, Shoolini University, Solan 173229, India.
² Department of Chemistry, Changwon National University, Changwon 51140, Korea.
³ Laboratory of Biological Active Macromolecular Systems, Institute of Bioorganic Chemistry, Uzbekistan Academy of Sciences, Tashkent 100125, Uzbekistan.
⁴ Department of Pharmaceutical Chemistry, Tashkent Pharmaceutical Institute, Tashkent 100015, Uzbekistan.
⁵ State Center for Expertise and Standardization of Medicines, Medical Devices, and Medical Equipment, State Unitary Enterprise, Tashkent 100002, Uzbekistan.
⁶ Department of Chemistry, School of Physical and Mineral Sciences, University of Limpopo, Polokwane 0727, South Africa.
⁷ Department of Physics, Faculty of Science, University of Zabol, Zabol 538-98615, Iran.
⁸ Department of Chemistry, College of Natural Sciences, Yeungnam University, 280 Daehak-Ro, Gyeongsan 38541, Korea.

Abstract

Globally, cancer is affecting societies and is becoming an important cause of death. Chemotherapy can be highly effective, but it is associated with certain problems, such as undesired targeting and multidrug resistance. The other advanced therapies, such as gene therapy and peptide therapy, do not prove to be effective without a proper delivery medium. Polymer-based hybrid nanoarchitectures have enormous potential in drug delivery. The polymers used in these nanohybrids (NHs)provide them with their distinct properties and also enable the controlled release of the drugs. This review features the recent use of polymers in the preparation of different nanohybrids for cancer therapy published since 2015 in some reputed journals. The polymeric nanohybrids provide an advantage in drug delivery with the controlled and targeted delivery of a payload and the irradiation of cancer by chemotherapeutical and photodynamic therapy.

Keywords: cancer therapy; chitosan-based nanohybrids; drug delivery; pH-based targeting; polymeric nanohybrids.

Publication types

Review

Grants and funding

M.S., S.A., and S.A are thankful to the Ministry of Innovative Development of the Republic of Uzbekistan for the research fund grant number PZ-2021022512 under the project Development of technologies for targeted drug delivery with a long duration of action and increased safety based on nanostructured carriers.