High prevalence of fatigue in patients with Takayasu arteritis: a case-control study in a Brazilian centre

Alexandre Moura Dos Santos; Rafael Giovani Misse; Isabela Bruna Pires Borges; Sarah Luiza Gomes da Silva; Ana Woo Sook Kim; Rosa Maria R Pereira; Samuel Katsuyuki Shinjo

doi:10.1093/rap/rkac054

High prevalence of fatigue in patients with Takayasu arteritis: a case-control study in a Brazilian centre

Rheumatol Adv Pract. 2022 Jul 21;6(2):rkac054. doi: 10.1093/rap/rkac054. eCollection 2022.

Authors

Alexandre Moura Dos Santos¹, Rafael Giovani Misse¹, Isabela Bruna Pires Borges¹, Sarah Luiza Gomes da Silva¹, Ana Woo Sook Kim¹, Rosa Maria R Pereira¹, Samuel Katsuyuki Shinjo¹

Affiliation

¹ Division of Rheumatology, Faculdade de Medicina FMUSP, Universidade de Sao Paulo, Sao Paulo, Brazil.

Abstract

Objectives: Several studies have shown not only a high prevalence of fatigue but also a reduction in health-related quality of life (HRQoL) in patients with rheumatic diseases. Owing to insufficient research in this area, we aimed to assess the prevalence of fatigue and its contribution to impairment of HRQoL in patients with Takayasu arteritis (TAK).

Methods: This single-centre case-control study included 53 TAK patients who were matched by age, BMI and sex with 100 healthy individuals. Aside from the patients' general data, the following information was collected: disease activity, level of activities of daily living (HAQ), physical activity levels and chronic fatigue.

Results: The TAK patients and healthy individuals were comparable in terms of current age, BMI and sex distribution. The median disease duration of TAK was 13.0 (7.0-20.0) years, and 11 (20.8%) patients had active disease. Compared with healthy individuals, patients with TAK had a higher prevalence of fatigue and lower HAQ score, physical activity level and intensity, and physical and psychosocial domains of the modified fatigue impact scale (P < 0.01). Moreover, TAK patients had increased fatigue rates compared with the healthy individuals (fatigue severity scale: odds ratio = 2.6; 95% CI = 1.2, 5.4; modified fatigue impact scale: odds ratio = 2.6; 95% CI = 1.2, 5.5). Fatigue was positively correlated with worsening HAQ, CRP levels, daily prednisone dose and disease activity, and negatively correlated with disease duration.

Conclusion: TAK patients have a higher prevalence of fatigue, which affects different aspects of the disease, including physical function. Thus, fatigue-focused treatments should also be considered in clinical practice.

Trial registration: The Brazilian Clinical Trials Registry (ReBEC), https://ensaiosclinicos.gov.br/, RBR-9n4z2hh.

Keywords: Takayasu arteritis; chronic fatigue syndrome; health-related quality of life; systemic vasculitis.