The Correlation Between Peroxisome Proliferator-Activated Receptor Alpha and Gamma Polymorphisms and Acute Coronary Syndrome

Aykut Kemanci; Tarik Goren; Mehmet Uluturk; Atakan Yilmaz; Ramazan Sabirli; Mert Ozen; Murat Seyit; Alten Oskay; Aylin Koseler; Ibrahim Turkcuer

doi:10.7759/cureus.26147

The Correlation Between Peroxisome Proliferator-Activated Receptor Alpha and Gamma Polymorphisms and Acute Coronary Syndrome

Cureus. 2022 Jun 21;14(6):e26147. doi: 10.7759/cureus.26147. eCollection 2022 Jun.

Authors

Affiliations

¹ Emergency Medicine, Tavsanli Doc. Dr. Mustafa Kalemli State Hospital, Kutahya, TUR.
² Emergency Department, Medical Faculty, Pamukkale University, Deni̇zli̇, TUR.
³ Emergency Department, Medical Faculty, Pamukkale University, Denizli, TUR.
⁴ Emergency Department, Bakircay University Faculty of Medicine Cigli Training and Research Hospital, Izmir, TUR.
⁵ Biophysics Department, Medical Faculty, Pamukkale University, Denizli, TUR.

Abstract

Objective: This study aims to evaluate the relationship between peroxisome proliferator-activated receptor (PPAR) alpha and gamma gene polymorphisms and acute coronary syndrome (ACS) clinically.

Subject and methods: Peripheral blood samples were collected from a total of 200 people, including 100 acute coronary syndrome patients and 100 controls aged 19 to 93 years, admitted to the Pamukkale University Emergency Medicine Department. The healthy volunteers had no known chronic or acute diseases, no history of drug use, and no recent history of coronary artery disease (CAD). PPAR alpha L162V and PPAR gamma C161T gene polymorphic regions were detected using DNA sequencing analyses. In addition, data collected from the hemogram and biochemical parameters and comorbidities of the patients were statistically analyzed.

Results: PPAR gamma C161T polymorphisms were compared between groups. The CT heterozygous rate in the patient group (74%) was higher than in the control group (7%). The T allele was more common in the patient group (0.37) compared to the control group (0.03). When PPAR alpha L162V polymorphism was compared, VV homozygous individuals were %19 in the patient group and none in the control group. The V allele was found to be statistically higher in patients with ACS (p<0.01).

Conclusion: The findings revealed that elevated PPAR alpha L162V and PPAR gamma C161T gene polymorphisms were associated with a progressive risk of ACS.

Keywords: acute coronary syndrome; coronary heart disease; mutation; polymorphism; ppar alpha; ppar gamma.