Locally Applied Repositioned Hormones for Oral Bone and Periodontal Tissue Engineering: A Narrative Review

Gamal Abdel Nasser Atia; Hany K Shalaby; Mehrukh Zehravi; Mohamed Mohamady Ghobashy; Zubair Ahmad; Farhat S Khan; Abhijit Dey; Md Habibur Rahman; Sang Woo Joo; Hasi Rani Barai; Simona Cavalu

doi:10.3390/polym14142964

Locally Applied Repositioned Hormones for Oral Bone and Periodontal Tissue Engineering: A Narrative Review

Polymers (Basel). 2022 Jul 21;14(14):2964. doi: 10.3390/polym14142964.

Authors

Affiliations

¹ Department of Oral Medicine, Periodontology, and Diagnosis, Faculty of Dentistry, Suez Canal University, Ismailia P.O. Box 41522, Egypt.
² Department of Oral Medicine, Periodontology and Oral Diagnosis, Faculty of Dentistry, Suez University, Suez P.O. Box 43512, Egypt.
³ Department of Clinical Pharmacy Girls Section, Prince Sattam Bin Abdul Aziz University, Al-Kharj 11942, Saudi Arabia.
⁴ Radiation Research of Polymer Chemistry Department, National Center for Radiation Research and Technology (NCRRT), Egyptian Atomic Energy Authority, P.O. Box 8029, Cairo 13759, Egypt.
⁵ Unit of Bee Research and Honey Production, Faculty of Science, King Khalid University, P.O. Box 9004, Abha 61413, Saudi Arabia.
⁶ Biology Department, College of Arts and Sciences, Dehran Al-Junub, King Khalid University, P.O. Box 9004, Abha 61413, Saudi Arabia.
⁷ Department of Life Sciences, Presidency University, Kolkata 700073, India.
⁸ Department of Global Medical Science, Wonju College of Medicine, Yonsei University, Wonju 26426, Korea.
⁹ School of Mechanical and IT Engineering, Yeungnam University, Gyeongsan 38541, Korea.
¹⁰ Faculty of Medicine and Pharmacy, University of Oradea, Piata 1 Decembrie 10, 410087 Oradea, Romania.

Abstract

Bone and periodontium are tissues that have a unique capacity to repair from harm. However, replacing or regrowing missing tissues is not always effective, and it becomes more difficult as the defect grows larger. Because of aging and the increased prevalence of debilitating disorders such as diabetes, there is a considerable increase in demand for orthopedic and periodontal surgical operations, and successful techniques for tissue regeneration are still required. Even with significant limitations, such as quantity and the need for a donor area, autogenous bone grafts remain the best solution. Topical administration methods integrate osteoconductive biomaterial and osteoinductive chemicals as hormones as alternative options. This is a promising method for removing the need for autogenous bone transplantation. Furthermore, despite enormous investigation, there is currently no single approach that can reproduce all the physiologic activities of autogenous bone transplants. The localized bioengineering technique uses biomaterials to administer different hormones to capitalize on the host's regeneration capacity and capability, as well as resemble intrinsic therapy. The current study adds to the comprehension of the principle of hormone redirection and its local administration in both bone and periodontal tissue engineering.

Keywords: bone; drug repositioning; hormones; periodontium; tissue engineering.

Publication types

Review

Grants and funding

The authors from King Khalid University extend their appreciation to the Deanship of Scientific Research at King Khalid University for funding this work through Research Groups Program under Grant No. R.G.P.2/149/43. This work was funded by grant NRF- 2019R1A5A8080290 of the National Research Foundation of Korea.