Promotion of Hair Regrowth by Transdermal Dissolvable Microneedles Loaded with Rapamycin and Epigallocatechin Gallate Nanoparticles

Yali Lin; Ruomei Shao; Tong Xiao; Shuqing Sun

doi:10.3390/pharmaceutics14071404

Promotion of Hair Regrowth by Transdermal Dissolvable Microneedles Loaded with Rapamycin and Epigallocatechin Gallate Nanoparticles

Pharmaceutics. 2022 Jul 4;14(7):1404. doi: 10.3390/pharmaceutics14071404.

Authors

Yali Lin^{1

2}, Ruomei Shao¹, Tong Xiao^{1

3}, Shuqing Sun¹

Affiliations

¹ Institute of Biopharmaceutical and Health Engineering, Shenzhen International Graduate School, Tsinghua University, Shenzhen 518055, China.
² Department of Biomedical Engineering, Tsinghua University, Beijing 100084, China.
³ Department of Chemical Engineering, Tsinghua University, Beijing 100084, China.

Abstract

Interest in transdermal delivery methods for stimulating hair regrowth has been increasing recently. The microneedle approach can break the barrier of the stratum corneum through puncture ability and improve drug delivery efficiency. Herein, we report a dissolvable microneedle device for the co-delivery of rapamycin and epigallocatechin gallate nanoparticles that can significantly promote hair regeneration. Compared with the mice without any treatment, our strategy can facilitate hair growth within 7 days. Higher hair shaft growth rate and hair follicle density with inconspicuous inflammation were exhibited in C57BL/6 mice, elucidating its potential for clinical application.

Keywords: hair regrowth; microneedles; nanoparticles; rapamycin.

Grants and funding

This research was funded by the National Natural Science Foundation of China (Grant No. 21874082) and Fundamental Research Program of Shenzhen (Committee of Scientific and Technological Innovation of Shenzhen) (JCYJ20170413104646428 and JCYJ20170307153548350).