Sustainable Green Synthesis of Yttrium Oxide (Y2O3) Nanoparticles Using Lantana camara Leaf Extracts: Physicochemical Characterization, Photocatalytic Degradation, Antibacterial, and Anticancer Potency

Rajakumar Govindasamy; Mydhili Govindarasu; Salman S Alharthi; Preeyanghaa Mani; Neppolian Bernaurdshaw; Thandapani Gomathi; Mohammad Azam Ansari; Mohammad N Alomary; Banan Atwah; M Shaheer Malik; V Devi Rajeswari; Kaliaperumal Rekha; Saleh A Ahmed; Muthu Thiruvengadam

doi:10.3390/nano12142393

Sustainable Green Synthesis of Yttrium Oxide (Y₂O₃) Nanoparticles Using Lantana camara Leaf Extracts: Physicochemical Characterization, Photocatalytic Degradation, Antibacterial, and Anticancer Potency

Nanomaterials (Basel). 2022 Jul 13;12(14):2393. doi: 10.3390/nano12142393.

Authors

Rajakumar Govindasamy¹, Mydhili Govindarasu², Salman S Alharthi³, Preeyanghaa Mani⁴, Neppolian Bernaurdshaw⁴, Thandapani Gomathi⁵, Mohammad Azam Ansari⁶, Mohammad N Alomary⁷, Banan Atwah⁸, M Shaheer Malik⁹, V Devi Rajeswari¹⁰, Kaliaperumal Rekha¹¹, Saleh A Ahmed^{9

12}, Muthu Thiruvengadam^{13

14}

Affiliations

¹ Collaborative Innovation Center for Advanced Organic Chemical Materials Co-Constructed by the Province and Ministry, Ministry of Education Key Laboratory for the Synthesis and Application of Organic Functional Molecules and College of Chemistry and Chemical Engineering, Hubei University, Wuhan 430062, China.
² Molecular Oncology Laboratory, Department of Biochemistry, Periyar University, Salem 636011, Tamil Nadu, India.
³ Department of Chemistry, College of Science, Taif University, P.O. Box 110999, Taif 21944, Saudi Arabia.
⁴ Nanotechnology & SRM Research Institute, SRM Institute of Science and Technology, Kattankulathur, Chennai 603203, India.
⁵ Department of Chemistry, D.K.M. College for Women, Vellore 632001, Tamil Nadu, India.
⁶ Department of Epidemic Disease Research, Institute for Research and Medical Consultations (IRMC), Imam Abdulrahman Bin Faisal University, Dammam 31441, Saudi Arabia.
⁷ National Centre for Biotechnology, King Abdulaziz City for Science and Technology (KACST), P.O. Box 6086, Riyadh 11442, Saudi Arabia.
⁸ Laboratory Medicine Department, Faculty of Applied Medical Sciences, Umm Al-Qura University, Makkah P.O. Box 7607, Saudi Arabia.
⁹ Department of Chemistry, Faculty of Applied Sciences, Umm Al-Qura University, Makkah 21955, Saudi Arabia.
¹⁰ Department of Biomedical Sciences, School of Biosciences and Technology, VIT, Vellore 632014, Tamil Nadu, India.
¹¹ Department of Environmental and Herbal Science, Tamil University, Thanjavur 613005, Tamil Nadu, India.
¹² Department of Chemistry, Faculty of Science, Assiut University, Assiut 71516, Egypt.
¹³ Department of Applied Bioscience, School of Life and Environmental Science, Konkuk University, Seoul 05029, Korea.
¹⁴ Department of Microbiology, Saveetha Dental College, Saveetha Institute of Medical and Technical Sciences (SIMATS), Chennai 600077, India.

Abstract

Due to their appropriate physicochemical properties, nanoparticles are used in nanomedicine to develop drug delivery systems for anticancer therapy. In biomedical applications, metal oxide nanoparticles are used as powerful and flexible multipurpose agents. This work described a green synthesis of Y₂O₃ nanoparticles (NPs) using the sol-gel technique with the use of aqueous leaf extracts of Lantana camara L (LC). These nanoparticles were characterized with the aid of different methods, including UV, X-ray diffraction (XRD), Fourier transformed infrared spectroscopy (FTIR), transmitted electron microscopy (TEM), and photocatalytic degradation. Y₂O₃ nanoparticles showed excellent antibacterial activity against Gram-positive Bacillus subtilis and Gram-negative Escherichia coli with a 10 to 15 mm inhibitory zone. Green Y₂O₃ NPs were released with a 4 h lag time and 80% sustained release rate, indicating that they could be used in drug delivery. In addition, the bioavailability of green Y₂O₃ NPs was investigated using cell viability in cervical cancer cell lines. These green-synthesized Y₂O₃ NPs demonstrated photocatalytic degradation, antibacterial, and anticancer properties.

Keywords: HeLa cells; Lantana camara; Y2O3 nanoparticles; cervical cancer; photocatalytic degradation.

Grants and funding

This research received no external funding.