Gut Microbiome in Inflammatory Bowel Disease: Role in Pathogenesis, Dietary Modulation, and Colitis-Associated Colon Cancer

John Gubatan; Theresa Louise Boye; Michelle Temby; Raoul S Sojwal; Derek R Holman; Sidhartha R Sinha; Stephan R Rogalla; Ole Haagen Nielsen

doi:10.3390/microorganisms10071371

Gut Microbiome in Inflammatory Bowel Disease: Role in Pathogenesis, Dietary Modulation, and Colitis-Associated Colon Cancer

Microorganisms. 2022 Jul 7;10(7):1371. doi: 10.3390/microorganisms10071371.

Authors

John Gubatan¹, Theresa Louise Boye², Michelle Temby¹, Raoul S Sojwal¹, Derek R Holman¹, Sidhartha R Sinha¹, Stephan R Rogalla¹, Ole Haagen Nielsen²

Affiliations

¹ Division of Gastroenterology and Hepatology, Stanford University School of Medicine, Stanford, CA 94305, USA.
² Department of Gastroenterology, Medical Section, Herlev Hospital, University of Copenhagen, DK-2730 Copenhagen, Denmark.

Abstract

The gut microbiome has increasingly been recognized as a critical and central factor in inflammatory bowel disease (IBD). Here, we review specific microorganisms that have been suggested to play a role in the pathogenesis of IBD and the current state of fecal microbial transplants as a therapeutic strategy in IBD. We discuss specific nutritional and dietary interventions in IBD and their effects on gut microbiota composition. Finally, we examine the role and mechanisms of the gut microbiome in mediating colitis-associated colon cancer.

Keywords: Crohn’s disease; colon cancer; diet; gut microbiome; immunity; inflammatory bowel disease; ulcerative colitis.

Publication types

Review

Grants and funding

JG is in part supported by a Chan Zuckerberg Biohub Physician Scientist Scholar Award, NIH NIDDK LRP Award (L30 DK126220), and a Doris Duke Physician Scientist Fellowship Award (Grant #2021091).