Phage Products for Fighting Antimicrobial Resistance

Yuanling Huang; Wenhui Wang; Zhihao Zhang; Yufeng Gu; Anxiong Huang; Junhao Wang; Haihong Hao

doi:10.3390/microorganisms10071324

Phage Products for Fighting Antimicrobial Resistance

Microorganisms. 2022 Jun 30;10(7):1324. doi: 10.3390/microorganisms10071324.

Authors

Yuanling Huang^{1

2}, Wenhui Wang^{1

2}, Zhihao Zhang^{1

2}, Yufeng Gu^{1

2}, Anxiong Huang^{1

2}, Junhao Wang^{1

2}, Haihong Hao^{1

2

3

4}

Affiliations

¹ National Reference Laboratory of Veterinary Drug Residues, Huazhong Agricultural University, Wuhan 430070, China.
² MOA Laboratory for Risk Assessment of Quality and Safety of Livestock and Poultry Products, Huazhong Agricultural University, Wuhan 430070, China.
³ Shenzhen Institute of Nutrition and Health, Huazhong Agricultural University, Shenzhen 518000, China.
⁴ Shenzhen Branch, Guangdong Laboratory for Lingnan Modern Agriculture, Genome Analysis Laboratory of the Ministry of Agriculture, Agricultural Genomics Institute at Shenzhen, Chinese Academy of Agricultural Sciences, Shenzhen 518000, China.

Abstract

Antimicrobial resistance (AMR) has become a global public health issue and antibiotic agents have lagged behind the rise in bacterial resistance. We are searching for a new method to combat AMR and phages are viruses that can effectively fight bacterial infections, which have renewed interest as antibiotic alternatives with their specificity. Large phage products have been produced in recent years to fight AMR. Using the "one health" approach, this review summarizes the phage products used in plant, food, animal, and human health. In addition, the advantages and disadvantages and future perspectives for the development of phage therapy as an antibiotic alternative to combat AMR are also discussed in this review.

Keywords: advantages and disadvantages of phage therapy; antimicrobial resistance; development prospects; phage products.

Publication types

Review

Grants and funding

This work was funded by grants from National Key Research and Development Program (2021YFD1800600), National Natural Science Foundation of China (32172914), Fundamental Research Funds for the Central Universities (2662022DKYJC005).