Genome-Wide Association Study Identifies Multiple Susceptibility Loci for Malignant Neoplasms of the Brain in Taiwan

Jang-Chun Lin; Yi-Chieh Wu; Fu-Chi Yang; Jo-Ting Tsai; David Yc Huang; Wei-Hsiu Liu

doi:10.3390/jpm12071161

Genome-Wide Association Study Identifies Multiple Susceptibility Loci for Malignant Neoplasms of the Brain in Taiwan

J Pers Med. 2022 Jul 18;12(7):1161. doi: 10.3390/jpm12071161.

Authors

Jang-Chun Lin^{1

2}, Yi-Chieh Wu³, Fu-Chi Yang⁴, Jo-Ting Tsai^{1

2}, David Yc Huang⁵, Wei-Hsiu Liu^{3

6}

Affiliations

¹ Department of Radiation Oncology, Shuang Ho Hospital, Taipei Medical University, Taipei 11031, Taiwan.
² Department of Radiology, School of Medicine, College of Medicine, Taipei Medical University, Taipei 11031, Taiwan.
³ Department of Neurological Surgery, Tri-Service General Hospital, National Defense Medical Center, No.325, Section 2, Cheng-Kung Road, Taipei 11490, Taiwan.
⁴ Department of Neurology, Tri-Service General Hospital, National Defense Medical Center, No. 325, Section 2, Cheng-Kung Road, Neihu 114, Taipei 11490, Taiwan.
⁵ Department of Medical Physics, Duke University, Durham, NC 27708, USA.
⁶ Department of Surgery, School of Medicine, National Defense Medical Center, Taipei 11490, Taiwan.

Abstract

Primary brain malignancy is a rare tumor with a global incidence of less than 10 per 100,000 people. Hence, there is limited power for identifying risk loci in individual studies, especially for Han Chinese. We performed a genome-wide association study (GWAS) in Taiwan, including 195 cases and 195 controls. We identified five new genes for malignant neoplasms of the brain: EDARADD (rs645507, 1p31.3, p = 7.71 × 10^-5, odds ratio (OR) = 1.893), RBFOX1 (rs8044700, p = 2.35 × 10^-5, OR = 2.36), LMF1 (rs3751667, p = 7.24 × 10^-7, OR = 2.17), DPP6 (rs67433368, p = 8.32 × 10^-5, OR = 3.94), and NDUFB9 (rs7827791, p = 9.73 × 10^-6, OR = 4.42). These data support that genetic susceptibility toward GBM or non-GBM tumors is highly distinct, likely reflecting different etiologies. Combined with signaling analysis, we found that RNA modification may be related to major risk factors in primary malignant neoplasms of the brain.

Keywords: LMF1; RBFOX1; SNP; brain cancer; glioma.

Abstract

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