Childhood B-Cell Preleukemia Mouse Modeling

Marta Isidro-Hernández; Silvia Alemán-Arteaga; Ana Casado-García; Belén Ruiz-Corzo; Susana Riesco; Pablo Prieto-Matos; Jorge Martínez-Cano; Lucía Sánchez; César Cobaleda; Isidro Sánchez-García; Carolina Vicente-Dueñas

doi:10.3390/ijms23147562

Childhood B-Cell Preleukemia Mouse Modeling

Int J Mol Sci. 2022 Jul 8;23(14):7562. doi: 10.3390/ijms23147562.

Authors

Marta Isidro-Hernández^{1

2}, Silvia Alemán-Arteaga^{1

2}, Ana Casado-García^{1

2}, Belén Ruiz-Corzo^{1

2}, Susana Riesco^{2

3}, Pablo Prieto-Matos^{2

3}, Jorge Martínez-Cano⁴, Lucía Sánchez⁵, César Cobaleda⁴, Isidro Sánchez-García^{1

2}, Carolina Vicente-Dueñas^{2

3}

Affiliations

¹ Experimental Therapeutics and Translational Oncology Program, Instituto de Biología Molecular y Celular del Cáncer, CSIC-USAL, Campus M. de Unamuno s/n, 37007 Salamanca, Spain.
² Institute for Biomedical Research of Salamanca (IBSAL), 37007 Salamanca, Spain.
³ Department of Pediatrics, Hospital Universitario de Salamanca, Paseo de San Vicente, 58-182, 37007 Salamanca, Spain.
⁴ Immune System Development and Function Unit, Centro de Biología Molecular Severo Ochoa (Consejo Superior de Investigaciones Científicas-Universidad Autónoma de Madrid), 28049 Madrid, Spain.
⁵ School of Law, University of Salamanca, 37007 Salamanca, Spain.

Abstract

Leukemia is the most usual childhood cancer, and B-cell acute lymphoblastic leukemia (B-ALL) is its most common presentation. It has been proposed that pediatric leukemogenesis occurs through a "multi-step" or "multi-hit" mechanism that includes both in utero and postnatal steps. Many childhood leukemia-initiating events, such as chromosomal translocations, originate in utero, and studies so far suggest that these "first-hits" occur at a far higher frequency than the incidence of childhood leukemia itself. The reason why only a small percentage of the children born with such preleukemic "hits" will develop full-blown leukemia is still a mystery. In order to better understand childhood leukemia, mouse modeling is essential, but only if the multistage process of leukemia can be recapitulated in the model. Therefore, mouse models naturally reproducing the "multi-step" process of childhood B-ALL will be essential to identify environmental or other factors that are directly linked to increased risk of disease.

Keywords: childhood leukemia; genetic predisposition; leukemia; mouse modeling; preleukemic cells.

Publication types

Review

MeSH terms

Animals
Disease Models, Animal
Humans
Mice
Myelodysplastic Syndromes*
Precursor Cell Lymphoblastic Leukemia-Lymphoma* / genetics
Preleukemia* / genetics
Translocation, Genetic

Grants and funding

Research in CV-D group has been funded by Instituto de Salud Carlos III (ISCIII), through a “Miguel Servet Grant” (CPII19/00024-AES 2017–2020); co-funded by the European Union. Research in IS-G group is partially supported by FEDER and by SAF2015-64420-R MINECO/FEDER, UE, RTI2018-093314-B-I00 MCIU/AEI/FEDER, UE, by PID2021-122185OB-I00 MCIU/AEI/FEDER, UE, and by Junta de Castilla y León (UIC-017, CSI001U16, CSI234P18, and CSI144P20). IS-G have been supported by the Fundacion Unoentrecienmil (CUNINA project). CC and IS-G have been supported by the Fundación Científica de la Asociación Española contra el Cáncer (PRYCO211305SANC). Research at CC’s laboratory was partially supported by Ministerio de Ciencia e Innovación/AEI/FEDER (PID2021-122787OB-I00), FEDER MINECO (SAF2017-83061-R), the “Fundación Ramón Areces” and a Research Contract with the “Fundación Síndrome de Wolf-Hirschhorn o 4p-”. Institutional grants from the “Fundación Ramón Areces” and “Banco de Santander” to the CBMSO are also acknowledged. J.M.-C. is the recipient of a UAM FPU fellowship. AC-G (CSI067-18) and MI-H (CSI021-19) are supported by FSE-Conserjería de Educación de la Junta de Castilla y León 2019 and 2020 (ESF—European Social Fund) fellowship, respectively. SA-A is supported by an Ayuda para Contratos predoctorales para la formación de doctores (PRE2019-088887). L.S. is supported by a scholarship from University of Salamanca co-financed by Banco Santander and ESF.