Management of Type 2 Diabetes Mellitus in Elderly Patients with Frailty and/or Sarcopenia

Jaime Sanz-Cánovas; Almudena López-Sampalo; Lidia Cobos-Palacios; Michele Ricci; Halbert Hernández-Negrín; Juan José Mancebo-Sevilla; Elena Álvarez-Recio; María Dolores López-Carmona; Luis Miguel Pérez-Belmonte; Ricardo Gómez-Huelgas; Maria Rosa Bernal-López

doi:10.3390/ijerph19148677

Management of Type 2 Diabetes Mellitus in Elderly Patients with Frailty and/or Sarcopenia

Int J Environ Res Public Health. 2022 Jul 16;19(14):8677. doi: 10.3390/ijerph19148677.

Authors

Jaime Sanz-Cánovas^{1

2}, Almudena López-Sampalo^{1

2}, Lidia Cobos-Palacios^{1

2}, Michele Ricci^{1

2}, Halbert Hernández-Negrín^{1

2}, Juan José Mancebo-Sevilla^{1

2}, Elena Álvarez-Recio^{1

2}, María Dolores López-Carmona^{1

2}, Luis Miguel Pérez-Belmonte^{1

2}, Ricardo Gómez-Huelgas^{1

2

3}, Maria Rosa Bernal-López^{1

2

3}

Affiliations

¹ Unidad de Gestión Clínica de Medicina Interna, Hospital Regional Universitario de Málaga, Universidad de Málaga (UMA), 29010 Málaga, Spain.
² Instituto de Investigación Biomédica de Málaga (IBIMA-Plataforma Bionand), 29590 Málaga, Spain.
³ Centro de Investigación Biomédica en Red Fisiopatología de la Obesidad y Nutrición (CIBERobn), Instituto de Salud Carlos III, 28029 Madrid, Spain.

Abstract

The life expectancy of the population is increasing worldwide due to improvements in the prevention, diagnosis, and treatment of diseases. This favors a higher prevalence of type 2 diabetes mellitus (T2DM) in the elderly. Sarcopenia and frailty are also frequently present in aging. These three entities share common mechanisms such as insulin resistance, chronic inflammation, and mitochondrial dysfunction. The coexistence of these situations worsens the prognosis of elderly patients. In this paper, we review the main measures for the prevention and management of sarcopenia and/or frailty in elderly patients with T2DM.

Keywords: elderly; frailty; sarcopenia; type 2 diabetes mellitus.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Aged
Aging
Diabetes Mellitus, Type 2* / complications
Diabetes Mellitus, Type 2* / epidemiology
Diabetes Mellitus, Type 2* / therapy
Frail Elderly
Frailty* / complications
Frailty* / epidemiology
Humans
Sarcopenia* / diagnosis
Sarcopenia* / epidemiology
Sarcopenia* / therapy

Grants and funding

This work was supported by grants from the Instituto de Salud Carlos III, cofunded by the Fondo Europeo de Desarrollo Regional-FEDER, grant PI18/00766 and “Centros de Investigación En Red” (CIBER, CB06/03/0018). Jaime Sanz Cánovas, Lidia Cobos Palacios, and Almudena López-Sampalo were supported by “Rio Hortega” program (CM20/00212, CM20/00125 and, CM21/00110, respectively) and M Rosa Bernal-Lopez was supported by “Miguel Servet Type II” program (CPII/00014) from the ISCIII-Madrid (Spain), cofunded by the Fondo Europeo de Desarrollo Regional-FEDER. M Rosa Bernal Lopez (“Nicolas Monardes” program, C1-0005-2020) was supported by Consejeria de Salud, Junta de Andalucía and Halbert Hernandez Negrin (PREDOC-00826) was supported by Consejería de Transformación Económica, Industria, Conocimiento y Universidades.