Effects of Traditional Chinese Exercise on Oxidative Stress in Middle-Aged and Older Adults: A Network Meta-Analysis

Delong Chen; Guanggao Zhao; Jingmei Fu; Shunli Sun; Xiaoxiao Huang; Liqiang Su; Zihao He; Ting Huang; Ruiming Chen; Xuewen Hu; Tianle Jiang; Minghui Quan

doi:10.3390/ijerph19148276

Effects of Traditional Chinese Exercise on Oxidative Stress in Middle-Aged and Older Adults: A Network Meta-Analysis

Int J Environ Res Public Health. 2022 Jul 6;19(14):8276. doi: 10.3390/ijerph19148276.

Authors

Delong Chen¹, Guanggao Zhao¹, Jingmei Fu², Shunli Sun², Xiaoxiao Huang¹, Liqiang Su³, Zihao He⁴, Ting Huang¹, Ruiming Chen¹, Xuewen Hu¹, Tianle Jiang¹, Minghui Quan⁵

Affiliations

¹ School of Physical Education, Nanchang University, Nanchang 330031, China.
² Jiangxi Sports Science Medicine Center, Nanchang 330006, China.
³ Physical Education College, Jiangxi Normal University, Nanchang 330022, China.
⁴ School of Sports and Human Sciences, Beijing Sport University, Beijing 100091, China.
⁵ School of Kinesiology, Shanghai University of Sport, Shanghai 200438, China.

Abstract

Objective: To evaluate the best option among traditional Chinese exercises for reducing oxidative stress in middle-aged and older adults, using a network meta-analysis.

Methods: PubMed, Web of Science, and CNKI databases were used. We searched randomized controlled trials (RCTs) on middle-aged and older adults to influence oxidative stress by any traditional Chinese exercises from the beginning to 20 January 2022. A network meta-analysis of randomized control trials was performed comparing the changes in the concentration of glutathione peroxidase (GPX), malondialdehyde (MDA), and superoxide dismutase (SOD) as primary outcomes, following different therapeutic interventions with traditional Chinese exercises in middle-aged and older adults over 30 years old. Standardized mean differences (SMD) and 95% confidence intervals (CI) were used to assess the correlation between each group of interventions, and surface under the cumulative ranking (SUCRA) was used to rank the best interventions.

Results: The meta-analysis comprised 15 trials with a total of 927 participants and six interventions: (Wuqinxi (WQX), Baduanjin (BDJ), Tai Ji Quan (TJQ), Yijinjing (YJJ), Mawangdui Daoyin (MWD), and no exercise intervention (NEI)). Regarding GPX: WQX [SMD = 2.79 (1.75, 3.83)], TJQ [SMD = 0.47 (0.23, 0.70)], YJJ [SMD = 1.78 (1.18, 2.37)], MWD [SMD = 1.89 (1.36, 2.43)] were superior in increasing GPX relative to NEI. Regarding MDA: WQX [SMD = 1.68 (0.94, 2.42)], YJJ [SMD = 0.99 (0.28, 1.69)] were superior in reducing MDA relative to NEI. Regarding SOD: WQX [SMD = 1.05 (0.10, 2.01)] were superior in increasing SOD relative to NEI. WQX topped the SUCRA with GPX: 0.97, MDA: 0.91, and SOD: 0.94. Furthermore, WQX was more effective than TJQ in interfering with GPX [SMD = 2.32 (1.26, 3.39)] and MDA [SMD = 1.47 (0.26, 2.67)], and a significantly better intervention effect on SOD than YJJ [SMD = 1.52 (0.80, 2.24)] and MWD [SMD = 0.89 (0.03, 1.75)].

Conclusion: Traditional Chinese exercise can help middle-aged and older adults reduce oxidative stress. WQX may be the best traditional Chinese exercise of the exercises evaluated for reducing oxidative stress in middle-aged and older adults.

Keywords: network meta-analysis; oxidative stress; traditional Chinese exercises.

Publication types

Meta-Analysis
Review
Research Support, Non-U.S. Gov't

MeSH terms

Adult
Aged
China
Exercise*
Glutathione Peroxidase
Humans
Middle Aged
Network Meta-Analysis
Oxidative Stress*
Superoxide Dismutase

Substances

Glutathione Peroxidase
Superoxide Dismutase

Grants and funding

This research was funded by The National Social Science Fund of China, grant number 21BTY088.