Review of Drug Therapy for Peripheral Facial Nerve Regeneration That Can Be Used in Actual Clinical Practice

Soo Young Choi; Jung Min Kim; Junyang Jung; Dong Choon Park; Myung Chul Yoo; Sung Soo Kim; Sang Hoon Kim; Seung Geun Yeo

doi:10.3390/biomedicines10071678

Review of Drug Therapy for Peripheral Facial Nerve Regeneration That Can Be Used in Actual Clinical Practice

Biomedicines. 2022 Jul 12;10(7):1678. doi: 10.3390/biomedicines10071678.

Authors

Soo Young Choi¹, Jung Min Kim¹, Junyang Jung², Dong Choon Park³, Myung Chul Yoo⁴, Sung Soo Kim⁵, Sang Hoon Kim¹, Seung Geun Yeo¹

Affiliations

¹ Department of Otolaryngology Head & Neck Surgery, College of Medicine, Kyung Hee University, Seoul 02447, Korea.
² Department of Anatomy and Neurobiology, College of Medicine, Kyung Hee University, Seoul 02447, Korea.
³ Department of Obstetrics and Gynecology, St. Vincent's Hospital, The Catholic University of Korea, Suwon 14647, Korea.
⁴ Department of Physical Medicine & Rehabilitation, College of Medicine, Kyung Hee University, Seoul 02447, Korea.
⁵ Medical Research Center for Bioreaction to Reactive Oxygen Species and Biomedical Science Institute, Graduate School, College of Medicine, Kyung Hee University, Seoul 02447, Korea.

Abstract

Although facial nerve palsy is not a life-threatening disease, facial asymmetry affects interpersonal relationships, causes psychological stress, and devastates human life. The treatment and rehabilitation of facial paralysis has many socio-economic costs. Therefore, in cases of facial paralysis, it is necessary to identify the cause and provide the best treatment. However, until now, complete recovery has been difficult regardless of the treatment used in cases of complete paralysis of unknown cause and cutting injury of the facial nerve due to disease or accident. Therefore, this article aims to contribute to the future treatment of facial paralysis by reviewing studies on drugs that aid in nerve regeneration after peripheral nerve damage.

Keywords: drug; facial nerve; peripheral nerve; regeneration.

Publication types

Review

Grants and funding

This work was supported by a National Research Foundation of Korea (NRF) grant funded by the Korean government (NRF 2018R1A6A1A03025124) (NRF 2019R1A2C1086807).