Osteoporosis is a systemic skeletal disease characterized by low bone mass and deterioration of the fine structures of bone tissue, with a consequent increase in bone fragility and susceptibility to fracture. Although studied mainly in postmenopausal women, osteoporosis has been recognized as a prevalent disease in men through similar mechanisms (ie, age-related bone loss, hormonal alterations, and other conditions/risk factors associated with bone loss). However, larger bone size, later onset of increased bone resorption, and lower fall risk are protective factors in men leading to a lower lifetime risk of fracture: 53.2% among women versus 20.7% among men. Despite a lower risk of fracture, for unclear reasons, men have higher rates of osteoporotic fracture-related complications and mortality than women.