Association between retinal sensitivity and the presence of quiescent choroidal neovascularization in pachychoroid diseases

Rion Ozawa; Keiko Azuma; Yoko Nomura; Hiroshi Murata; Ryo Asaoka; Kohdai Kitamoto; Kohei Ueda; Tatsuya Inoue; Ryo Obata

doi:10.1371/journal.pone.0271543

Association between retinal sensitivity and the presence of quiescent choroidal neovascularization in pachychoroid diseases

PLoS One. 2022 Jul 26;17(7):e0271543. doi: 10.1371/journal.pone.0271543. eCollection 2022.

Authors

Rion Ozawa¹, Keiko Azuma¹, Yoko Nomura¹, Hiroshi Murata¹, Ryo Asaoka², Kohdai Kitamoto¹, Kohei Ueda¹, Tatsuya Inoue³, Ryo Obata¹

Affiliations

¹ Graduate School of Medicine and Faculty of Medicine, Department of Ophthalmology, The University of Tokyo, Tokyo, Japan.
² Department of Ophthalmology, Seirei Hamamatsu General Hospital, Seirei Christopher University, Shizuoka, Japan.
³ Department of Ophthalmology and Micro-Technology, Yokohama City University School of Medicine, Minami-ku, Yokohama, Kanagawa, Japan.

Abstract

This study was conducted to examine retinal sensitivity (RS) in eyes with pachychoroid diseases and to analyze its association with the presence or absence of quiescent choroidal neovascularization (CNV), that can be protective against retinal dysfunction or atrophy in other macular diseases such as age-related macular degeneration. A total of 12 eyes of 12 patients aged ≥45 years having the characteristic findings of central serous chorioretinopathy but not presenting any exudative changes were included in this study. Choroidal vascular hyper permeability (CVH) was identified by indocyanine green angiography, and the presence or absence of CNV was evaluated by optical coherence tomography angiography. RS at 68 points was examined by microperimetry. The average RS corresponding to within and outside CVH was compared. The association between the difference in RS and the presence or absence of CNV was also analyzed. CNV was detected in six eyes (50%). In eyes without CNV, the RS within CVH was similar compared with that outside CVH. However, in eyes with CNV, the RS within CVH was significantly decreased compared with that outside CVH. Multiple regression analysis revealed the presence of CNV as an independent factor associated with RS. In eyes with pachychoroid diseases, RS decreased within the CVH area under the coexistence of nonexudative CNV.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Central Serous Chorioretinopathy* / complications
Central Serous Chorioretinopathy* / diagnostic imaging
Choroid / blood supply
Choroidal Neovascularization* / diagnostic imaging
Fluorescein Angiography
Humans
Retrospective Studies
Tomography, Optical Coherence

Grants and funding

This study was funded by Japan Society for The Promotion of Science (Grant Number 21K16893). The funding organization had no role in the design or conduct of this research. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.