Direct fluoroalkoxylation reactions of (hetero)arenes, carbon-carbon multiple bonds, and substitution reactions at Csp3 carbon centers by CF3 O, CHF2 O, and (CF3 )2 CFO groups are discussed. Emphasis on thermal radical, electron transfer, photocatalytic, electrochemical and redox-neutral radical methods are placed to accomplish fluoroalkoxylation reactions. All these methods employ either radical fluoroalkoxylating reagents or some nucleophilic trifluoromethoxylating sources of CF3 O. A summary of all these methods is provided in Table 2.
Keywords: (hetero)arenes; carbon-carbon multiple bonds; redox-neutral radical reaction; substitution at Csp3; trifluoromethoxylation.
© 2022 Wiley-VCH GmbH.