Tumor microenvironment responsive nanocarriers for gene therapy

Yanhua Li; Kun Tang; Xia Zhang; Wei Pan; Na Li; Bo Tang

doi:10.1039/d2cc02759c

Tumor microenvironment responsive nanocarriers for gene therapy

Chem Commun (Camb). 2022 Aug 4;58(63):8754-8765. doi: 10.1039/d2cc02759c.

Authors

Yanhua Li¹, Kun Tang¹, Xia Zhang¹, Wei Pan¹, Na Li¹, Bo Tang¹

Affiliation

¹ College of Chemistry, Chemical Engineering and Materials Science, Key Laboratory of Molecular and Nano Probes, Ministry of Education, Collaborative Innovation Center of Functionalized Probes for Chemical Imaging in Universities of Shandong, Institute of Molecular and Nano Science, Shandong Normal University, Jinan 250014, P. R. China. lina@sdnu.edu.cn.

PMID: 35880654
DOI: 10.1039/d2cc02759c

Abstract

Stimuli responsive nanocarriers are important non-viral gene carriers for gene therapy. We discuss the stimulus conditions and then highlight various stimuli responsive nanocarriers in the tumor microenvironment for cancer gene therapy. We hope that this review will inspire readers to develop more effective stimuli responsive nanocarriers for delivering genes.

Publication types

Review

MeSH terms

Drug Carriers / therapeutic use
Drug Delivery Systems
Genetic Therapy
Humans
Nanoparticles*
Neoplasms* / drug therapy
Tumor Microenvironment

Substances

Drug Carriers