A new abietane diterpene tuurgan a from caryopteris mongholica

Nayintai Dai; Qinghu Wang; Meirong Bai; Liguo Yang; Yu Zhao

doi:10.1080/14786419.2022.2098738

A new abietane diterpene tuurgan a from caryopteris mongholica

Nat Prod Res. 2023 Oct-Nov;37(21):3663-3667. doi: 10.1080/14786419.2022.2098738. Epub 2022 Jul 25.

Authors

Nayintai Dai^{1

2}, Qinghu Wang², Meirong Bai², Liguo Yang², Yu Zhao¹

Affiliations

¹ Jilin Ginseng Academy, Changchun University of Chinese Medicine, Changchun, Jilin, China.
² Key Laboratory of Mongolian Medicine Research and Development Ministry of Education, College of Traditional Mongolian Medicine, Inner Mongolia Minzu University, Tongliao, Inner Mongolia, China.

PMID: 35879815
DOI: 10.1080/14786419.2022.2098738

Abstract

Five abietane diterpenes compounds were separated from petroleum ether extraction sites of ethanol extract of Caryopteris Mongholica, and Compound 1 was identified as a new abietane diterpenes compound by NMR and mass spectrometry, named as Tuurgan A of Caryopteris Mongholica; and Compounds 2-5 separated from Caryopteris Mongholica for the first time were identified as Ferruginol (2), Taxodione (3), Caryopterisoid Q (4), and Huperphlegmarin B (5). The anti-lung cancer activity of the Compounds 1-5 were determined, which results showed that they all had high A549 cytotoxicity.

Keywords: A549 cytotoxicity; Caryopteris Mongholica; abietane diterpenes; Tuurgan A of Caryopteris Mongholica.