Effects of insomnia and levels of depression and anxiety symptoms on quality of life in people with epilepsy

Rui Zhong; Zhuan Li; Qingling Chen; Hanyu Zhang; Xinyue Zhang; Weihong Lin

doi:10.1186/s12888-022-04154-0

Effects of insomnia and levels of depression and anxiety symptoms on quality of life in people with epilepsy

BMC Psychiatry. 2022 Jul 25;22(1):497. doi: 10.1186/s12888-022-04154-0.

Authors

Rui Zhong¹, Zhuan Li², Qingling Chen³, Hanyu Zhang¹, Xinyue Zhang¹, Weihong Lin⁴

Affiliations

¹ Department of Neurology, The First Hospital of Jilin University, Changchun, China.
² Department of Emergency, Linyi Central Hospital, Linyi, China.
³ Department of Hepatology, Second People's Clinical College of Tianjin Medical University, Tianjin, China.
⁴ Department of Neurology, The First Hospital of Jilin University, Changchun, China. linwh@jlu.edu.cn.

Abstract

Objectives: The association between insomnia and quality of life (QOL) in epilepsy is poorly understood and may involve interactive variables. We aimed to investigate whether and how insomnia, levels of depression and anxiety symptoms interact to influence QOL in people with epilepsy (PWE).

Methods: A consecutive cohort of 179 PWE was enrolled. We collected data on insomnia, levels of depression and anxiety symptoms, and QOL. The Insomnia Severity Index (ISI), Depression Inventory for Epilepsy (NDDI-E), Generalized Anxiety Disorder-7 (GAD-7), and QOL in Epilepsy Inventory (QOLIE-31) were used. The direct, indirect, and total effects of insomnia on QOL were estimated based on a moderated mediation model.

Results: Depression symptom levels mediated the association between insomnia and QOL (B = 0.09 SE = 0.03, p = 0.01). Depression symptom levels accounted for 34.7% of the total effect of insomnia on QOL. The mediating effect of depression symptom levels was positively moderated by anxiety symptom levels (B = 0.09, SE = 0.03, p = 0.01).

Conclusion: The effect of insomnia on QOL can be partially explained by the mediation of depression symptom levels. Additionally, improving anxiety symptoms may attenuate the indirect effect of insomnia on QOL through depression symptom levels.

Keywords: Anxiety symptom levels; Depression symptom levels; Insomnia; People with epilepsy; Quality of life.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Anxiety / complications
Depression / complications
Epilepsy* / complications
Humans
Quality of Life
Sleep Initiation and Maintenance Disorders* / complications