Mosaicism for the smooth muscle cell (SMC)-specific knock-in of the Acta2 R179C pathogenic variant: Implications for gene editing therapies

J Mol Cell Cardiol. 2022 Oct:171:102-104. doi: 10.1016/j.yjmcc.2022.07.004. Epub 2022 Jul 22.

¹ Division of Medical Genetics, Department of Internal Medicine, McGovern Medical School, University of Texas Health Science Center at Houston, TX 77030, USA.
² Department of Cardiothoracic Surgery, Stanford University School of Medicine, Stanford, CA 94305, United States of America.
³ Division of Medical Genetics, Department of Internal Medicine, McGovern Medical School, University of Texas Health Science Center at Houston, TX 77030, USA. Electronic address: Dianna.M.Milewicz@uth.tmc.edu.

No abstract available

Keywords: Acta2; Gene therapy; Genetic mouse models; Thoracic aortic aneurysms and dissections; Vascular smooth muscle cells.

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