Zoonotic Threat of G4 Genotype Eurasian Avian-Like Swine Influenza A(H1N1) Viruses, China, 2020

Min Gu; Kaibiao Chen; Zhichuang Ge; Jun Jiao; Tianyu Cai; Suhan Liu; Xiaoquan Wang; Xinan Jiao; Daxin Peng; Xiufan Liu

doi:10.3201/eid2808.212530

Zoonotic Threat of G4 Genotype Eurasian Avian-Like Swine Influenza A(H1N1) Viruses, China, 2020

Emerg Infect Dis. 2022 Aug;28(8):1664-1668. doi: 10.3201/eid2808.212530.

Authors

Min Gu, Kaibiao Chen, Zhichuang Ge, Jun Jiao, Tianyu Cai, Suhan Liu, Xiaoquan Wang, Xinan Jiao, Daxin Peng, Xiufan Liu

Abstract

We investigated genetic and biologic characteristics of 2 Eurasian avian-like H1N1 swine influenza viruses from pigs in China that belong to the predominant G4 genotype. One swine isolate exhibited strikingly great homology to contemporaneous human Eurasian avian-like H1N1 isolates, preferential binding to the human-type receptor, and vigorous replication in mice without adaptation.

Keywords: China; Eurasian avian-like H1N1; G4 genotype; H1N1; influenza; swine influenza; viruses; zoonoses.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Birds
China / epidemiology
Genotype
Humans
Influenza A Virus, H1N1 Subtype* / genetics
Influenza, Human* / epidemiology
Mice
Orthomyxoviridae Infections* / veterinary
Phylogeny
Reassortant Viruses / genetics
Swine
Swine Diseases* / epidemiology